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P1490

Sigma-Aldrich

Pepsinogen I human

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About This Item

CAS Number:
92228-49-4
MDL number:
MFCD03457958
UNSPSC Code:
12352202

Key Documents

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biological source

human

form

liquid

specific activity

≥500 U/mg (Lowry)

UniProt accession no.

P0DJD7
P0DJD8
P0DJD9
P20142

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PGA3(643834), PGA4(643847), PGA5(5222), PGC(5225)

Biochem/physiol Actions

Studies show that smoking has an effect on the level of pepsinogen I present in serum in a H. pylori-dependent manner. Patients with lower titer levels had higher levels of pepsinogen I.
Used as a control in ELISA.

Physical form

0.2 μm filtered solution in Tris chloride, pH 8.5

Other Notes

One unit will produce a delta A280 of 0.001 per min at pH 2.0 at 37 deg C, measured as TCA-soluble products using hemoglobin as substrate. (Final Volume of reaction mixture = 16mL, 1 cm light path)

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH0026V
SLBH0026
SLBF1090
SLBD7708
SLBC4968

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the molecular weight for Pepsinogen from human, Product P1490?

    The UniProt accession number is P0DJD7. Uniprot provides a molecular weight of 41,977, based on a 388 amino acid sequence.Note that pepsinogen is the full-length protein. This can be processed (removing the first 62 amino acids), to generate the active enzyme Pepsin. Please note that Sigma does not determine the sequence,  molecular weight nor the purity for  product P1490. This enzyme is released on the basis of the specific activity as noted on the specification sheet at our website.

  6. What is the source tissue for Product P1490, Pepsinogen I from human?

    The biological source of pepsinogen I human is human stomach. This information is provided on the lot specific Certificate of Origin (CofO) located at our website.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

M Tatemichi et al.
Japanese journal of cancer research : Gann, 92(3), 243-248 (2001-03-27)
Serum pepsinogen (sPG) levels are used in gastric cancer screening programs. However, modification of sPG levels by smoking habit, according to the status of Helicobacter pylori (H. pylori) infection has been little investigated. This study investigated the effects of smoking

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