P159
Pertussis toxin B oligomer
solid
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About This Item
UNSPSC Code:
12352200
MDL number:
form
solid
color
white
storage temp.
2-8°C
Biochem/physiol Actions
Subunit of pertussis toxin responsible for binding to cell surfaces; stimulates both platelet aggregation and cytosolic Ca2+ level elevation, may also activate phospholipase C; isolated from B pertussis strain 165.
Preparation Note
Each vial contains 40 μg of protein which may be reconstituted with either sterile distilled water or sterile buffer.
Disclaimer
Do not freeze. Do not subject to sterile filtration, as this will result in loss of material.
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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M Tamura et al.
The Journal of biological chemistry, 258(11), 6756-6761 (1983-06-10)
Islet-activating protein (IAP), pertussis toxin, is an oligomeric protein (Tamura, M., Nogimori, K., Murai, S., Yajima, M., Ito, K., Katada, T., Ui, M., and Ishii, S. (1982) Biochemistry 21, 5516-5522), the biggest subunit (Mr = 28,000, referred to as the
C F Strnad et al.
FEBS letters, 225(1-2), 16-20 (1987-12-10)
Pertussis toxin was found to serve as a mitogen in the human T lymphocyte, an effect which could be mimicked by its resolved binding component, the B oligomer. The mechanism of action of this component appeared to involve a rapid
H S Banga et al.
The Journal of biological chemistry, 262(31), 14871-14874 (1987-11-05)
The activation of phospholipase C in human platelets is coupled to agonist receptors via guanine nucleotide-binding protein(s), and prior treatment of permeabilized platelets with GTP gamma S, GDP beta S, or pertussis toxin modifies platelet responses to agonists. Pertussis toxin
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