biological source
bovine kidney
Quality Level
Assay
≥90% (SDS-GE)
form
buffered aqueous glycerol solution
specific activity
~2 U/vial
mol wt
36 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
bovine ... PPP2CA(282320)
General description
Protein phosphatase 2 catalytic subunit a (PPP2CA/PP2Ac) gene is mapped to human chromosome 5q31.1. The PPP2CA gene encodes the catalytic subunit of PP2A (protein phosphatase 2), a serine/threonine phosphatase.
Biochem/physiol Actions
Divalent cation-independent catalytic subunit of protein phosphatase 2A. Useful for functional studies of the A and B subunit of the phosphatase.
Protein phosphatase 2 catalytic subunit α (PPP2CA/PP2Ac) is a tumor suppressor and negatively regulates cell cycle. It mainly regulates PI3K (phosphatidylinositol 3-kinase)/AKT (RAC-α serine/threonine-protein kinase) pathway, MEK1 (MAPK/ERK kinase 1), ERK (extracellular signal-regulated kinase) family kinases and c-myc transcription factors.
Physical form
1 μg per vial in 50 μl of 50 mM Tris-HCl, pH 7.0, containing 14 mM β-Mercaptoethanol, 1mM benzamidine, 0.1 mM PMSF, 1mM EDTA, and 50% glycerol.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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