P1641
5α-Pregnane-3β,11β,17α,21-tetrol-20-one
Synonym(s):
3β,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one, 3β,5α-Tetrahydrocortisol, 3β-Allotetrahydrocortisol, Reichstein’s substance V
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
Empirical Formula (Hill Notation):
C21H34O5
CAS Number:
Molecular Weight:
366.49
UNSPSC Code:
41116107
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Andrea Raffaelli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 278-285 (2005-11-29)
The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) is responsible for the interconversion of both the hormonally inactive cortisone and the active cortisol. This enzyme activity, which has implications in the pathogenesis of numerous diseases, is reflected in the ratio of tetrahydrometabolites of cortisol
Franciszek K Główka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 283-289 (2009-12-19)
11Beta-hydroxysteroid dehydrogenase isoform 2 (11beta-HSD2) is responsible for conversion of cortisol (F) to inactive cortisone (E). Disturbance of its activity can cause hypertension. To estimate 11beta-HSD2 activity, besides F and E, their tetrahydro- (THF, THE) as well allo-tetrahydro- (allo-THF, allo-THE)
Anil Mongia et al.
The Journal of clinical endocrinology and metabolism, 97(10), 3622-3629 (2012-08-09)
The mineralocorticoid receptor is protected from excess of glucocorticoids by conversion of active cortisol to inactive cortisone by enzyme 11β-hydroxysteroid dehydrogenase type 2 present in the kidney. The metabolites of cortisol and cortisone are excreted in the urine as tetrahydrocortisol
P W Raven et al.
Endocrine research, 22(4), 811-815 (1996-11-01)
The increased ratio of 5 alpha to 5 beta reduced steroids associated with apparent mineralocorticoid excess (AME) may be a necessary consequence of altered 11 beta-hydroxysteroid dehydrogenase (11-HSD) activity. In order to test this hypothesis we have compared changes in
J Müller-Berghaus et al.
Acta paediatrica (Oslo, Norway : 1992), 85(1), 111-113 (1996-01-01)
We report the case of a 16-month-old boy who presented with chronic vomiting, failure to thrive, arterial hypertension and medullary nephrocalcinosis. Laboratory results revealed hypokalaemia, metabolic alkalosis, increased urinary potassium excretion and a hyporeninaemic hypoaldosteronism. Chromatographic determination of urinary steroid
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service