P1648
5β-Pregnane-3β,11β,17α,21-tetrol-20-one
Synonym(s):
3β,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one, 3β-Tetrahydrocortisol
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About This Item
Empirical Formula (Hill Notation):
C21H34O5
CAS Number:
Molecular Weight:
366.49
UNSPSC Code:
12352200
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Franciszek K Główka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 283-289 (2009-12-19)
11Beta-hydroxysteroid dehydrogenase isoform 2 (11beta-HSD2) is responsible for conversion of cortisol (F) to inactive cortisone (E). Disturbance of its activity can cause hypertension. To estimate 11beta-HSD2 activity, besides F and E, their tetrahydro- (THF, THE) as well allo-tetrahydro- (allo-THF, allo-THE)
Andrea Raffaelli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 830(2), 278-285 (2005-11-29)
The 11beta-hydroxysteroid dehydrogenase (11beta-HSD) is responsible for the interconversion of both the hormonally inactive cortisone and the active cortisol. This enzyme activity, which has implications in the pathogenesis of numerous diseases, is reflected in the ratio of tetrahydrometabolites of cortisol
E M Freel et al.
Clinical endocrinology, 66(5), 659-665 (2007-03-27)
Corticosteroids can be synthesized in extra-adrenal tissues but the contribution of this to circulating levels in humans is not known. Previous in vitro studies suggest that the 'hybrid' corticosteroid 18-oxocortisol (18-oxoF) is produced from cortisol by aldosterone synthase. We looked
C H Shackleton et al.
Clinical endocrinology, 22(6), 701-712 (1985-06-01)
Four children with 11 beta-hydroxysteroid dehydrogenase deficiency are described. All patients had severe hypertension, hypokalaemia, and low plasma aldosterone and renin activities. Two of the patients were siblings and two were unrelated. The most noticeable biochemical feature of these individuals
A Vermeulen et al.
The Prostate, 14(1), 45-53 (1989-01-01)
The objective of this study was to estimate the minimum in vivo effective oral dose and duration of action of the competitive 5 alpha-reductase inhibitor MK-906, a 4-azasteroid, in humans. Plasma dihydrotesterone (DHT), 5 alpha-androstane-3 alpha,17 beta-diol (AD), and its
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