P1738
PARP-1 bovine
≥98% (SDS-PAGE), ≥300 U/mg, buffered aqueous glycerol solution
Synonym(s):
NAD+ ADP-ribosyltransferase, Poly(ADP-ribose) Polymerase, Poly(ADP-ribose) Synthetase
assay
≥98% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
≥300 U/mg
UniProt accession no.
storage temp.
−70°C
Gene Information
cow ... ADPRT(286764)
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Biochem/physiol Actions
PARP-1, a nuclear enzyme that synthesizes ADP-ribose polymers from NAD, specifically binds Zn2+ and DNA, and recognizes single-strand breaks in DNA. It is involved in base excision repair, both short-patch and long-patch, rejoining DNA strand breaks and plays a role in p53 expression and activation. A high level of basal neuronal DNA damage and PARP activity has been reported in rat brain tissue. PARP-1 was shown to be required for HIV-1 integration into DNA. If PARP-1 is deficient there is no productive HIV-1 infection.
Physical form
Solution in 50 mM Tris-HCl, pH 7.4, containing 1 M NaCl and 10 mM β-mercaptoethanol.
Other Notes
One unit synthesizes 1 nmol of poly(ADP-ribose)/min at pH 7.5 at 25 °C.
Regulatory Information
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