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P183

(+)-PD 128,907 hydrochloride

Name: (+)-PD 128,907 hydrochloride
Brand: SIGMA

>97%, solid

Synonym(s):

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₉NO₃ · HCl

CAS Number:

300576-59-4

Molecular Weight:

285.77

NACRES:

NA.77

PubChem Substance ID:

24277928

UNSPSC Code:

12352202

MDL number:

MFCD00210210

Assay:

>97%

Form:

solid

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assay

>97%

form

solid

color

off-white

solubility

ethanol: >10 mg/mL, DMSO: 18 mg/mL, H₂O: 9 mg/mL

SMILES string

Cl.CCCN1CCO[C@H]2[C@H]1COc3ccc(O)cc23

InChI

1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1

InChI key

DCFXOTRONMKUJB-QMDUSEKHSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

Selective D₃ dopamine receptor agonist.

Legal Information

Manufactured and sold with the permission of Warner-Lambert Company.

Disclaimer

Light sensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Assessment of cocaine-like discriminative stimulus effects of dopamine D₃ receptor ligands.

Acri, et al.

European Journal of Pharmacology, 281 (1995)

A functional test identifies dopamine agonists selective for D3 versus D2 receptors.

F Sautel et al.

Neuroreport, 6(2), 329-332 (1995-01-26)

The functional potency of a series of dopamine agonists for increasing mitogenesis, measured by incorporation of [3H]thymidine, was established in transfected cell lines expressing human D2 or D3 receptors. The functional selectivity of agonists markedly differs from their binding selectivity.

Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.

H A DeWald et al.

Journal of medicinal chemistry, 33(1), 445-450 (1990-01-01)

The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand [3H]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated

Chemical genetics reveals a complex functional ground state of neural stem cells.

Phedias Diamandis et al.

Nature chemical biology, 3(5), 268-273 (2007-04-10)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

Global Trade Item Number

SKU	GTIN
P183-25MG	04061832272894
P183-5MG	04061832092560

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