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Merck
CN

P204

Phenylbenzene ω-phosphono-α-amino acid

solid

Synonym(s):

3-[2′-Phosphonomethyl[1,1′-biphenyl]-3-yl]alanine, PMBA

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About This Item

Empirical Formula (Hill Notation):
C16H18NO5P
Molecular Weight:
335.29
UNSPSC Code:
12352200
PubChem Substance ID:
24278002
MDL number:
MFCD00467903

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InChI

1S/C16H18NO5P/c17-15(16(18)19)9-11-4-3-6-12(8-11)14-7-2-1-5-13(14)10-23(20,21)22/h1-8,15H,9-10,17H2,(H,18,19)(H2,20,21,22)/t15-/m0/s1

SMILES string

N[C@@H](Cc1cccc(c1)-c2ccccc2CP(O)(O)=O)C(O)=O

InChI key

NCEGJIHRQBRVJQ-HNNXBMFYSA-N

form

solid

color

white

solubility

H2O: 0.15 mg/mL, DMSO: 0.2 mg/mL, 0.1 M NaOH: >10 mg/mL

Gene Information

human ... GRIN1(2902)

Biochem/physiol Actions

Selective strychnine-sensitive glycine receptor antagonist.

Legal Information

Made and sold under license from Nippon Chemiphar.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
069K1205
037K1441
060K0753
054K0968

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T Saitoh et al.
British journal of pharmacology, 113(1), 165-170 (1994-09-01)
1. 3-[2'-Phosphonomethyl[1,1'-biphenyl]-3-yl]alanine (PMBA) is a novel glycine antagonist at strychnine-sensitive receptors. The chemical structure of PMBA, possessing both a glycine moiety and a phosphono group, is quite different from that of strychnine. 2. In the spinal motoneurone of newborn rats
K Watanabe et al.
Soft matter, 14(17), 3372-3377 (2018-04-06)
An external electric AC field with a field strength ranging from 10 V mm-1 to 30 V mm-1 and a frequency ranging from 0.1 kHz to 1 MHz was applied to suspensions of gold nanoparticles (Au NPs) to control their
Kanako Watanabe et al.
Journal of colloid and interface science, 566, 202-210 (2020-02-02)
Assembly of plasmonic nanoparticle clusters having hotspots in a specific space is an effective way to efficiently utilize their plasmonic properties. In the assembly, however, bulk-like aggregates of the nanoparticles are readily formed by strong van der Waals forces, inducing
Akihisa Otaka et al.
Journal of biomedical materials research. Part A, 108(10), 2090-2099 (2020-04-24)
Current chemotherapy methods have limited effectiveness in eliminating bone metastasis, which leads to a poor prognosis associated with severe bone disorders. To provide regional chemotherapy for this metastatic tumor, a bone-targeting drug carrier was produced by introducing the osteotropic bisphosphonate
Shahin Aghamiri et al.
IET nanobiotechnology, 13(8), 808-815 (2019-10-19)
Breast cancer is the second cause of death in the world. Ionising radiation is a potent mutagen that can cause DNA damage, chromosomes breakage, and cell death. In the present study, radiotherapy and nanoparticle-antibodies (ABs) have been combined to enhance
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