P2178
Pro-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C59H86N16O14
CAS Number:
Molecular Weight:
1243.41
UNSPSC Code:
12352200
MDL number:
SMILES string
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
assay
≥97% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
Cardioinhibitory; inhibits contraction of the oviduct visceral muscle, but potentiates contraction of the extensortibiae muscle
Other Notes
FMRF-amide-like neuropeptide originally isolated from locust (Schistocera gregaria)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Sharon R Hill et al.
Journal of insect physiology, 51(1), 1-9 (2005-02-03)
We have investigated the effect of the locust myosuppressin, SchistoFLRFamide, on the activity of amylase and alpha-glucosidase in the midgut of 2-week old male locusts. Total enzyme activity in the lumen contents and tissue extracts of midguts responds to SchistoFLRFamide
Mode of action of an inhibitory neuropeptide SchistoFLRFamide on the locust oviduct visceral muscle.
Z Wang et al.
Neuropeptides, 28(3), 147-155 (1995-03-01)
The possible mode of action of an inhibitory neuropeptide SchistoFLRFamide (PDVDHVFLRFamide) on locust oviduct visceral muscle was studied by examining its ability to inhibit calcium ionophore A23187-, caffeine- or phorbol ester-induced oviduct contractions. A23187-induced muscle contractions included two components: one
Angela Mousley et al.
International journal for parasitology, 34(6), 755-768 (2004-04-28)
FMRFamide-related peptides are common to a wide variety of invertebrate species, including helminths and arthropods. In arthropods, five distinct FMRFamide-related peptide subfamilies are recognised: the myosuppressins, extended-FLRFamides, -FMRFamides, -RFamides, and sulfakinins, members of which induce potent and diverse myotropic effects.
Z Wang et al.
Neuropeptides, 28(5), 261-266 (1995-05-01)
In the oviduct of Locusta migratoria, a FMRFamide-related peptide, PDVDHVFLRFamide (SchistoFLRFamide) acts as a neuromodulator, inhibiting spontaneous and induced muscle contraction. In this study, we have used N-terminal truncated peptides to show that PDVDHVFLRFamide has separated binding and activation regions.
J Clark et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 189(2), 105-114 (2003-02-28)
Octopamine was identified in the spermathecal tissue of Locusta migratoria using HPLC and immunohistochemical techniques. Octopamine-like immunoreactive unpaired median neurons were identified in the VIIth and VIIIth (terminal) abdominal ganglia and octopamine-like immunoreactive axons were present in the ventral ovipositor
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