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Merck
CN

P2178

Sigma-Aldrich

Pro-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C59H86N16O14
CAS Number:
Molecular Weight:
1243.41
MDL number:
UNSPSC Code:
12352200
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Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

Biochem/physiol Actions

Cardioinhibitory; inhibits contraction of the oviduct visceral muscle, but potentiates contraction of the extensortibiae muscle

Other Notes

FMRF-amide-like neuropeptide originally isolated from locust (Schistocera gregaria)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Sharon R Hill et al.
Journal of insect physiology, 51(1), 1-9 (2005-02-03)
We have investigated the effect of the locust myosuppressin, SchistoFLRFamide, on the activity of amylase and alpha-glucosidase in the midgut of 2-week old male locusts. Total enzyme activity in the lumen contents and tissue extracts of midguts responds to SchistoFLRFamide
Angela Mousley et al.
International journal for parasitology, 34(6), 755-768 (2004-04-28)
FMRFamide-related peptides are common to a wide variety of invertebrate species, including helminths and arthropods. In arthropods, five distinct FMRFamide-related peptide subfamilies are recognised: the myosuppressins, extended-FLRFamides, -FMRFamides, -RFamides, and sulfakinins, members of which induce potent and diverse myotropic effects.
Z Wang et al.
Neuropeptides, 28(3), 147-155 (1995-03-01)
The possible mode of action of an inhibitory neuropeptide SchistoFLRFamide (PDVDHVFLRFamide) on locust oviduct visceral muscle was studied by examining its ability to inhibit calcium ionophore A23187-, caffeine- or phorbol ester-induced oviduct contractions. A23187-induced muscle contractions included two components: one
Z Wang et al.
Neuropeptides, 28(5), 261-266 (1995-05-01)
In the oviduct of Locusta migratoria, a FMRFamide-related peptide, PDVDHVFLRFamide (SchistoFLRFamide) acts as a neuromodulator, inhibiting spontaneous and induced muscle contraction. In this study, we have used N-terminal truncated peptides to show that PDVDHVFLRFamide has separated binding and activation regions.
L S Swales et al.
Cell and tissue research, 281(2), 339-348 (1995-08-01)
SchistoFLRFamide (PDVDHVFLRF-NH2) is one of the major endogenous neuropeptides of the FMRFamide family found in the nervous system of the locust, Schistocerca gregaria. To gain insights into the potential physiological roles of this neuropeptide we have examined the distribution of

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