P2178
Pro-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C59H86N16O14
CAS Number:
Molecular Weight:
1243.41
UNSPSC Code:
12352200
MDL number:
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
Biochem/physiol Actions
Cardioinhibitory; inhibits contraction of the oviduct visceral muscle, but potentiates contraction of the extensortibiae muscle
Other Notes
FMRF-amide-like neuropeptide originally isolated from locust (Schistocera gregaria)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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S Robb et al.
Biochemical and biophysical research communications, 160(2), 850-856 (1989-04-28)
We have isolated a neuropeptide, related to the Phe-Met-Arg-Phe-NH2 family, from the thoracic nervous system of the locust, Schistocerca gregaria, using a purification system based on the radioimmunoassay of high pressure liquid chromatography fractions. The primary sequence of this locust
Z Wang et al.
Peptides, 16(7), 1181-1186 (1995-01-01)
In the oviduct of Locusta migratoria, an inhibitory neuropeptide, PDVDHVFLRFamide (SchistoFLRFamide) has separate binding and activation regions. VFLRFamide is the minimum sequence required for binding, which is comparable to the parent peptide, whereas the His residue, which does not contribute
A B Lange et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(20), 9250-9253 (1995-09-26)
We describe a nonpeptide mimetic analog of an invertebrate peptide receptor. Benzethonium chloride (Bztc) is an agonist of the SchistoFLRFamide (PDVDHVFLRFamide) receptors found on locust oviducts. Bztc competitively displaces [125I-labeled Y1]SchistoFLRFamide binding to both high- and low-affinity receptors of membrane
H G Vullings et al.
Journal of neurocytology, 27(12), 901-913 (2000-02-05)
The distribution and actions of FMRFamide-related peptides (FaRPs) in the corpora cardiaca of the locust Locusta migratoria were studied. Antisera to FMRFamide and SchistoFLRFamide (PDVDHVFLRFamide) label neuronal processes that impinge on glandular cells in the glandular lobe of the corpora
Rodney Kwok et al.
Peptides, 23(11), 1925-1932 (2002-11-15)
We have developed a semi-intact preparation-consisting of an isolated oviduct with abdominal ganglia VII and VIII intact and attached-with which to characterize the effects on oviduct contraction, of peptides that are bath applied to CNS tissues. The work presented here
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