P220
Peptide YY Fragment 3-36 human
≥95% (HPLC), lyophilized powder
General description
Human peptide YY (PYY) is a 36 amino acid peptide secreted by mucosal L cells in the distal ileum, colon and rectum. The gene encoding PYY is localized on human chromosome 17q21.1.
Biochem/physiol Actions
Y2/Y5 Neuropeptide Y receptor agonist. Human peptide YY (PYY) has roles in energy homeostasis, food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Disclaimer
Hygroscopic
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M Gué et al.
British journal of pharmacology, 118(2), 237-242 (1996-05-01)
1. The Y receptor subtype involved in the antagonism by neuropeptide Y (NPY) of intracisternal corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion was studied in urethane-anaesthetized rats by use of peptides with various selectivity for Y1, Y2 and Y3
R Abounader et al.
British journal of pharmacology, 116(4), 2245-2250 (1995-10-01)
1. We have characterized pharmacologically the receptor subtype(s) responsible for the neuropeptide Y (NPY)-induced vasoconstriction in human cerebral arteries. NPY, PYY and several of their derivatives with well defined affinities at the known Y1 and Y2 receptor subtypes were used.
Peptide YY and neuropeptide Y: two peptides intimately involved in electrolyte homeostasis.
R J Playford et al.
Trends in pharmacological sciences, 17(12), 436-438 (1996-12-01)
Expression of peptide YY by human blood leukocytes.
Holler JP
Peptides (2014)
Genomic and gene expression signature of the pre-invasive
testicular carcinoma in situ
testicular carcinoma in situ
Kristian Almstrup
Cell and Tissue Research (2005)
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