P2277
Calmodulin from bovine brain
~95% (SDS-PAGE), lyophilized powder
Synonym(s):
CaM, Phosphodiesterase 3′,5′-cyclic nucleotide activator from bovine brain
assay
~95% (SDS-PAGE)
form
lyophilized powder
specific activity
~40,000 units/mg protein (Lowry)
mol wt
16.8 kDa
impurities
salt, essentially free
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... CALM3(520277)
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Biochem/physiol Actions
Calmodulin is the Ca+2 dependent regulator protein (CDR), troponin C-like protein.
Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
Other Notes
One unit will stimulate 0.008 activated unit of phosphodiesterase, 3′:5′-cyclic nucleotide in a 3 ml reaction volume at pH 7.5 and 30 °C, to 50% of the maximum activity of the enzyme when saturated with activator, in the presence of 0.01 mM Ca2+.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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