Protein C from human plasma

Protein C is a plasma, vitamin K-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating factors Va and VIIIa.

Protein C is a plasma, vitamin K-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.

Purified Protein C forms a closely spaced doublet at a molecular weight of 62 kDa using SDS gel electrophoresis under non-reduced conditions.

Lyophilized from 20 mM Tris buffered saline, pH 7.4, containing 0.02% sodium azide

1 vial = 100 μg protein.

Protein C is purified from a concentrate of pooled normal human plasma using an Anti-Protein C-Agarose column (Product No. A 0435) followed by gel filtration.

Reconstitute with 1 ml deionized water.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.