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Merck
CN

P2610

Sigma-Aldrich

Monoclonal Anti-p14ARF antibody produced in mouse

~2 mg/mL, clone DCS-240, purified immunoglobulin, buffered aqueous solution

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About This Item

MDL number:
MFCD02686484
UNSPSC Code:
12352203

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DCS-240, monoclonal

form

buffered aqueous solution

mol wt

antigen 14 kDa

species reactivity

human

concentration

~2 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
microarray: suitable
western blot: 1-2 μg/mL using a whole extract of HeLa cells

isotype

IgG1

UniProt accession no.

Q8N726

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CDKN2A(1029)

Immunogen

recombinant human p14ARF

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
100K4851

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Stuart Gallagher et al.
Cell cycle (Georgetown, Tex.), 4(3), 465-472 (2005-02-11)
Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic signaling by activating the p53 pathway, and the frequent loss of p14ARF in human cancer diminishes the duration
Helen Rizos et al.
The Journal of biological chemistry, 281(49), 38080-38088 (2006-10-13)
Alterations in the p14(ARF) tumor suppressor are frequent in many human cancers and are associated with susceptibility to melanoma, pancreatic cancer, and nervous system tumors. In addition to its p53-regulatory functions, p14(ARF) has been shown to influence ribosome biogenesis and
Ken Saito et al.
Cancer science, 107(9), 1290-1301 (2016-06-19)
p14(ARF) is one of the major tumor suppressors conventionally identified both as the mdm2-binding molecule restoring p53 function in the nucleus, and as a nucleophosmin-binding partner inside the nucleolous to stabilize ribosomal RNA. However, its recently reported mitochondrial localization has
Anna Budina-Kolomets et al.
Autophagy, 9(10), 1553-1565 (2013-08-14)
The ARF tumor suppressor, encoded by the CDKN2A gene, has a well-defined role regulating TP53 stability; this activity maps to exon 1β of CDKN2A. In contrast, little is known about the function(s) of exon 2 of ARF, which contains the
Nuria Eritja et al.
Molecular cancer therapeutics, 13(4), 776-787 (2014-01-23)
Mutations in fibroblast growth factor receptor 2 (FGFR2) have been recently described as a molecular-specific feature in endometrial carcinomas and the presence of activated FGFR2 mutations is associated with poor prognosis. For that reason, inhibition of FGFR2 could be a
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