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Merck
CN

P2610

Monoclonal Anti-p14ARF antibody produced in mouse

~2 mg/mL, clone DCS-240, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
MDL number:
MFCD02686484

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DCS-240, monoclonal

form

buffered aqueous solution

mol wt

antigen 14 kDa

species reactivity

human

concentration

~2 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, microarray: suitable, western blot: 1-2 μg/mL using a whole extract of HeLa cells

isotype

IgG1

UniProt accession no.

Q8N726

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CDKN2A(1029)

Immunogen

recombinant human p14ARF

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
100K4851

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Stuart Gallagher et al.
Cell cycle (Georgetown, Tex.), 4(3), 465-472 (2005-02-11)
Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic signaling by activating the p53 pathway, and the frequent loss of p14ARF in human cancer diminishes the duration
Anna Budina-Kolomets et al.
Autophagy, 9(10), 1553-1565 (2013-08-14)
The ARF tumor suppressor, encoded by the CDKN2A gene, has a well-defined role regulating TP53 stability; this activity maps to exon 1β of CDKN2A. In contrast, little is known about the function(s) of exon 2 of ARF, which contains the
Ken Saito et al.
Cancer science, 107(9), 1290-1301 (2016-06-19)
p14(ARF) is one of the major tumor suppressors conventionally identified both as the mdm2-binding molecule restoring p53 function in the nucleus, and as a nucleophosmin-binding partner inside the nucleolous to stabilize ribosomal RNA. However, its recently reported mitochondrial localization has
Helen Rizos et al.
The Journal of biological chemistry, 281(49), 38080-38088 (2006-10-13)
Alterations in the p14(ARF) tumor suppressor are frequent in many human cancers and are associated with susceptibility to melanoma, pancreatic cancer, and nervous system tumors. In addition to its p53-regulatory functions, p14(ARF) has been shown to influence ribosome biogenesis and
A Macià et al.
Oncogene, 31(35), 3961-3972 (2011-12-14)
Medullary thyroid carcinoma (MTC) is a malignancy derived from the calcitonin-producing C-cells of the thyroid gland. Oncogenic mutations of the Ret proto-oncogene are found in all heritable forms of MTC and roughly one half of the sporadic cases. However, several
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