P3115
Protein Kinase C Inhibitor, Myristoylated
≥7.5 mg/mL (peptide and counter ion), ≥95% (Minimum peptide content 70%, HPLC), aqueous solution (neutral pH)
Synonym(s):
Myr-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val, Myr-RFARKGALRQKNV
biological source
synthetic (organic
organic)
Assay
≥95% (Minimum peptide content 70%, HPLC)
form
aqueous solution (neutral pH)
mol wt
1,754.3 Da (Fast Atomic Bombardment Mass Spectrometry)
1.75 kDa
composition
Peptide content, ≥70%
concentration
≥7.5 mg/mL (peptide and counter ion)
shipped in
dry ice
storage temp.
−20°C
Application
Protein Kinase C (PKC) Inhibitor, Myristoylated is supplied ready for use in kinase reactions. An inhibitor peptide (concentration of 50 to 100 μM) is recommended, depending on the concentration of PKC and the duration of the incubation.
Biochem/physiol Actions
Protein Kinase C Inhibitor, Myristoylated is a cell permeable, specific inhibitor of calcium and phospholipid-dependent Protein Kinase C.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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T Eichholtz et al.
The Journal of biological chemistry, 268(3), 1982-1986 (1993-01-25)
Synthetic peptides corresponding to the pseudosubstrate domains of protein kinase C (PKC) have been used as specific inhibitors of PKC in in vitro assays and permeabilized cell systems. However, their use in vivo was hampered by the impermeability of the
Katarzyna Bialkowska et al.
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We previously reported that genistein, a phytoestrogen, up-regulates endothelial nitric oxide synthase (eNOS) and prevents hypertension in rats that are independent of estrogen signaling machinery. However, how genistein regulates eNOS expression is unknown. In the present study, we show that
Samantha L Yuen et al.
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