P3246
Pipamperone dihydrochloride
~99% (HPLC), dopamine receptor antagonist, powder
Synonym(s):
1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050
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About This Item
Empirical Formula (Hill Notation):
C21H30N3O2F · 2HCl
CAS Number:
Molecular Weight:
448.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
219-507-5
MDL number:
Product Name
Pipamperone dihydrochloride, ~99% (HPLC), powder
assay
~99% (HPLC)
Quality Level
form
powder
color
white
solubility
H2O: >2.0 mg/mL
originator
Johnson & Johnson
SMILES string
Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
InChI
1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
InChI key
BMXXSXQVMCXGJM-UHFFFAOYSA-N
Application
Pipamperone dihydrochloride may be used:
- as an internal standard in liquid chromatography with coulometric detection
- as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
- as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis
Biochem/physiol Actions
Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.
D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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The treatment of autism with pipamperone: A case report
Petrosino B, et al.
European Psychiatry : The Journal of the Association of European Psychiatrists, 33, S682-S682 (2016)
P A Janssen et al.
Arzneimittel-Forschung, 44(3), 269-277 (1994-03-01)
In 1965 the first study of this series reported different effects of neuroleptics in rats, supporting clinical differences. At the one end, haloperidol presented as a potent and specific antagonist of the psychostimulants amphetamine and apomorphine. Haloperidol-like neuroleptics have marked
Eva Saar et al.
Journal of mass spectrometry : JMS, 45(8), 915-925 (2010-07-22)
Over the last decade, the prescription rates of antipsychotic (AP) drugs have increased worldwide. Studies have shown that the risk of sudden cardiac death is threefold higher among patients treated with APs. To investigate the presence of APs in postmortem
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P3246-100MG | 04061832092676 |