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P3246

Pipamperone dihydrochloride

Name: Pipamperone dihydrochloride
Brand: SIGMA

~99% (HPLC), dopamine receptor antagonist, powder

Synonym(s):

1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₀N₃O₂F · 2HCl

CAS Number:

2448-68-2

Molecular Weight:

448.40

NACRES:

NA.77

PubChem Substance ID:

24724576

UNSPSC Code:

12352200

EC Number:

219-507-5

MDL number:

MFCD00242980

Assay:

~99% (HPLC)

Form:

powder

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Properties

Product Name

Pipamperone dihydrochloride, ~99% (HPLC), powder

assay

~99% (HPLC)

Quality Segment

100

form

powder

color

white

solubility

H₂O: >2.0 mg/mL

originator

Johnson & Johnson

SMILES string

Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3

InChI

1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H

InChI key

BMXXSXQVMCXGJM-UHFFFAOYSA-N

Description

Application

Pipamperone dihydrochloride may be used:

as an internal standard in liquid chromatography with coulometric detection
as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis

Biochem/physiol Actions

Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.

D₂ dopamine receptor antagonist; 5-HT₂ serotonin receptor antagonist; antipsychotic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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