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Merck
CN

P3737

Sigma-Aldrich

Monoclonal Anti-p63 antibody produced in mouse

~2 mg/mL, clone 4A4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-B(p51A), Anti-B(p51B), Anti-EEC3, Anti-KET, Anti-TP63

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About This Item

MDL number:
MFCD02263451
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

200

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4A4, monoclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using whole extract of cultured human keratinocyte HaCaT cells

isotype

IgG2a

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TP63(8626)
mouse ... Trp63(22061)
rat ... Tp73l(246334)

General description

(P63) is a homologue of the (p53) family and encodes protein having similar amino acid sequence to that of( p53) transactivation domains, DNA binding domains, and oligomerization domains . It is highly expressed in basal or progenitor layers of epithelial tissues . Monoclonal anti-(p63) antibody can be used to study the molecular mechanisms by which (p63) can utilize dominant-negative and gain-of-function mutations involved in development. It can also be used in indirect ELISA and microarray. Mouse monoclonal anti-(p63) antibody reacts specifically with an epitope present in amino acids 1-205 of mouse Np63 isoform. It also reacts with (p63) in rats and humans.

Immunogen

recombinant N-terminal portion (amino acids 1-205) of mouse ΔNp63 isoform.

Application

Monoclonal anti-(p63) antibody can be used in immunoblotting, immunocytochemistry and immunohistochemistry. It may also be used for immunoprecipitation and western blot.

Legal Information

This product is licensed for RESEARCH USE ONLY under U.S. Patents Nos. 6,946,256 and 7,030,227 owned by Harvard College. Other uses of the Sigma product, for example in diagnostics or therapeutics, are outside the scope of the license and are not authorized. For products licensed for diagnostic use, consult AsymmetRx, Inc. by telephone at 203-228-0209 or by email at pmckeon@asymmetrix.com

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051K4894

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The p53 family: same response, different signals?
1. Chen, X
Molecular Medicine, 2, 387-392 (1999)
K M Liefer et al.
Cancer research, 60(15), 4016-4020 (2000-08-17)
In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B
Tzu-Wei Wang et al.
Artificial organs, 30(3), 141-149 (2006-02-17)
In order to develop an adequate scaffold for skin tissue engineering, a bilayered gelatin-chondroitin 6 sulfate-hyaluronic acid membrane with a different pore size on either side was prepared. A rete ridges-like topographic microporous structure, which provided the paracrine crosstalk in
Andreas Birbach et al.
Genesis (New York, N.Y. : 2000), 47(11), 757-764 (2009-10-16)
Tissue-specific transgene expression in the prostate epithelium has previously been achieved using short prostate-specific promoters, rendering transgenic mouse lines susceptible to integration site-dependent effects. Here we demonstrate the applicability of bacterial artificial chromosome (BAC) technology to transgene expression in the
p63 and p73: old members of a new family.
M C Marin et al.
Biochimica et biophysica acta, 1470(3), M93-M100 (2000-05-09)
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