Skip to Content
Merck
CN

P3737

Monoclonal Anti-p63 antibody produced in mouse

~2 mg/mL, clone 4A4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-B(p51A), Anti-B(p51B), Anti-EEC3, Anti-KET, Anti-TP63

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02263451

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4A4, monoclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1-2 μg/mL using whole extract of cultured human keratinocyte HaCaT cells

isotype

IgG2a

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TP63(8626)
mouse ... Trp63(22061)
rat ... Tp73l(246334)

Related Categories

General description

(P63) is a homologue of the (p53) family and encodes protein having similar amino acid sequence to that of( p53) transactivation domains, DNA binding domains, and oligomerization domains . It is highly expressed in basal or progenitor layers of epithelial tissues . Monoclonal anti-(p63) antibody can be used to study the molecular mechanisms by which (p63) can utilize dominant-negative and gain-of-function mutations involved in development. It can also be used in indirect ELISA and microarray. Mouse monoclonal anti-(p63) antibody reacts specifically with an epitope present in amino acids 1-205 of mouse Np63 isoform. It also reacts with (p63) in rats and humans.

Immunogen

recombinant N-terminal portion (amino acids 1-205) of mouse ΔNp63 isoform.

Application

Monoclonal anti-(p63) antibody can be used in immunoblotting, immunocytochemistry and immunohistochemistry. It may also be used for immunoprecipitation and western blot.

Legal Information

This product is licensed for RESEARCH USE ONLY under U.S. Patents Nos. 6,946,256 and 7,030,227 owned by Harvard College. Other uses of the Sigma product, for example in diagnostics or therapeutics, are outside the scope of the license and are not authorized. For products licensed for diagnostic use, consult AsymmetRx, Inc. by telephone at 203-228-0209 or by email at pmckeon@asymmetrix.com

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
051K4894

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The p53 family: same response, different signals?
1. Chen, X
Molecular Medicine, 2, 387-392 (1999)
K M Liefer et al.
Cancer research, 60(15), 4016-4020 (2000-08-17)
In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B
Tzu-Wei Wang et al.
Artificial organs, 30(3), 141-149 (2006-02-17)
In order to develop an adequate scaffold for skin tissue engineering, a bilayered gelatin-chondroitin 6 sulfate-hyaluronic acid membrane with a different pore size on either side was prepared. A rete ridges-like topographic microporous structure, which provided the paracrine crosstalk in
Andreas Birbach et al.
Genesis (New York, N.Y. : 2000), 47(11), 757-764 (2009-10-16)
Tissue-specific transgene expression in the prostate epithelium has previously been achieved using short prostate-specific promoters, rendering transgenic mouse lines susceptible to integration site-dependent effects. Here we demonstrate the applicability of bacterial artificial chromosome (BAC) technology to transgene expression in the
p63 and p73: old members of a new family.
M C Marin et al.
Biochimica et biophysica acta, 1470(3), M93-M100 (2000-05-09)
View All Related Papers

Related Content

Data Sheet - P3737

Instructions

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service