P3798
Pyruvate Dehydrogenase from Lactobacillus delbrueckii
lyophilized powder, ≥1 units/mg solid
form
lyophilized powder
specific activity
≥1 units/mg solid
storage temp.
2-8°C
Physical form
Lyophilized powder containing approx. 50% mannitol and FAD as stabilizers.
Other Notes
One unit will produce 1.0 μmole of acetyl phosphate and CO2 from pyruvate and inorganic phosphate per min at pH 6.3 at 37 °C.
Hazard Classifications
Resp. Sens. 1
signalword
Danger
hcodes
pcodes
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Suzanne D DeBrosse et al.
Molecular genetics and metabolism, 107(3), 394-402 (2012-10-02)
Pyruvate dehydrogenase complex (PDC) deficiency is a relatively common mitochondrial disorder that primarily presents with neurological manifestations and lactic acidemia. We analyzed the clinical outcomes and neurological features of 59 consented symptomatic subjects (27 M, 32 F), who were confirmed
Pyruvate dehydrogenase deficiency and the brain.
Garry Brown
Developmental medicine and child neurology, 54(5), 395-396 (2012-03-14)
Christoffer Laustsen et al.
Diabetes/metabolism research and reviews, 29(2), 125-129 (2012-11-21)
This experimental study explores a novel magnetic resonance imaging/spectroscopic (MRI/MRS) method that measures changes in renal metabolism in a diabetic rat model. This hyperpolarized metabolic MRI/MRS method allows monitoring of metabolic processes in seconds by >10 000-fold enhancement of the
Yasutoshi Koga et al.
Brain & development, 34(2), 87-91 (2011-04-02)
Leigh syndrome (LS) is a progressive untreatable degenerating mitochondrial disorder caused by either mitochondrial or nuclear DNA mutations. A patient was a second child of unconsanguineous parents. On the third day of birth, he was transferred to neonatal intensive care
Jong Kwang Hong et al.
Journal of biotechnology, 155(2), 225-231 (2011-07-05)
The effect of growth factor (GF) and sodium butyrate (NaBu) on Chinese hamster ovary (CHO) cell growth, cell viability and antibody production was investigated using shaking flasks in GF-containing and GF-deficient medium containing 0, 1 and 3mM NaBu. The withdrawal
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