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P4038

Polycytidylic acid-Polyguanylic acid sodium salt

Synonym(s):

Poly(C) • Poly(G)

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About This Item

CAS Number:
25280-45-9
UNSPSC Code:
41106305
MDL number:
MFCD00131959
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form

solid

storage temp.

−20°C

InChI

1S/C10H14N5O8P.C9H14N3O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t3-,5-,6-,9-;4-,6-,7-,8-/m11/s1

InChI key

SDYIDXSXVMJNAE-FBGCOTALSA-N

Application

Polycytidylic acid-Polyguanylic acid (polyGC), a synthetic polynucleotide, is a double stranded homodimer used for physicochemical analysis of RNA structure.

Other Notes

Double-stranded homopolymer

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
088K4042
037K4052
086K4012
035K4122
035K4121

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Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 24(6), 561-570 (2007-05-19)
PolyGC was titrated with a strong base in the presence of increasing concentrations of NaCl (from 0.00 to 0.60M) either in water solution or with the polynucleotide solubilized in the aqueous core of reverse micelles, i.e., the cationic quaternary water-in-oil
Hole mobility in DNA: effects of static and dynamic structural fluctuations.
Ferdinand C Grozema et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 3(6), 536-539 (2002-12-06)
Javier Robalino et al.
Journal of virology, 78(19), 10442-10448 (2004-09-16)
Vertebrates mount a strong innate immune response against viruses, largely by activating the interferon system. Double-stranded RNA (dsRNA), a common intermediate formed during the life cycle of many viruses, is a potent trigger of this response. In contrast, no general
Susanna Cogoi et al.
Cancer gene therapy, 11(7), 465-476 (2004-05-01)
The Ki-ras gene is frequently mutated and/or overexpressed in human cancer. Since it is suspected to play a key role in the pathogenesis of many tumors, there is interest to search for strategies aiming at the specific inhibition of this
Ai-Min Guo et al.
Physical review. E, Statistical, nonlinear, and soft matter physics, 78(6 Pt 1), 061922-061922 (2009-03-05)
We report a theoretical study highlighting the fundamental effects of backbone disorder which simulates the environmental complications on charge transport properties of biological and synthetic DNA molecules. Based on effective tight-binding models of duplex DNA, the Lyapunov coefficient and current-voltage
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