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P4404

Polyguanylic acid potassium salt

≥95% (TLC), enzyme from (synthesis), lyophilized powder

Synonym(s):

Poly(G) potassium salt

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About This Item

CAS Number:
54684-83-2
UNSPSC Code:
41106305
NACRES:
NA.51
MDL number:
MFCD00131976
Assay:
≥95% (TLC)
Biological source:
enzyme from (synthesis)
Form:
lyophilized powder
Solubility:
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow
Storage temp.:
−20°C
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Product Name

Polyguanylic acid potassium salt, lyophilized powder

biological source

enzyme from (synthesis)

Quality Segment

200

assay

≥95% (TLC)

form

lyophilized powder

quality

≤5% free nucleotides

solubility

water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow

storage temp.

−20°C

General description

Polyguanylic acid takes up a four-stranded helical structure. It is synthetically produced in Thermus thermophilus from guanosine diphosphate (GDP) and its synthesis is catalyzed by the enzyme polynucleotide phosphorylase.

Application

Polyguanylic acid potassium salt has been used:
  • as a ligand for surface neuropilin-1 (NRP1) for internalization studies
  • for intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry method
  • as a synthetic polynucleotide for agarose gel electrophoresis analysis

Polyguanylic acid (PolyG) is used to study the effects of ionizing radiation on formation and stability of G-quadruplex structures and as a target molecule for physicochemical studies of electronic excitation (vibrational spectra) of guanosine.

Biochem/physiol Actions

Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells.

Preparation Note

Prepared from GDP using polynucleotide phosphorylase

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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