P4484
Purvalanol A
≥98% (HPLC), powder
Synonym(s):
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60
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About This Item
Empirical Formula (Hill Notation):
C19H25ClN6O
CAS Number:
Molecular Weight:
388.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
solubility
methylene chloride: 50 mg/mL
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1
InChI
1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
InChI key
PMXCMJLOPOFPBT-HNNXBMFYSA-N
Biochem/physiol Actions
Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro. It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.
Features and Benefits
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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