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Merck
CN

P4631

Sigma-Aldrich

Phosphodiesterase I from Bothrops atrox

Type V, crude dried venom, ≥0.01 unit/mg solid

Synonym(s):

5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase

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About This Item

EC Number:
EC Number:
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.32
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type

Type V

form

crude dried venom

specific activity

≥0.01 unit/mg solid

storage temp.

−20°C

Other Notes

One unit will hydrolyze 1.0 μmole of bis(p-nitrophenyl) phosphate per min at pH 8.8 at 37 °C.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Aurora Mejía-Benítez et al.
BMC medical genetics, 14, 21-21 (2013-02-05)
Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some of these SNPs to obesity risk
Antonella Marucci et al.
Biochimica et biophysica acta, 1833(6), 1388-1395 (2013-03-19)
Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling and action. Understanding the mechanisms underlying ENPP1 expression may help unravel molecular mechanisms of insulin resistance. Recent data suggest a role of ENPP1-3'untraslated region (UTR), in controlling ENPP1 expression. We sought to
Brian L Foster et al.
PloS one, 7(6), e38393-e38393 (2012-06-08)
Inorganic pyrophosphate (PP(i)) is a physiologic inhibitor of hydroxyapatite mineral precipitation involved in regulating mineralized tissue development and pathologic calcification. Local levels of PP(i) are controlled by antagonistic functions of factors that decrease PP(i) and promote mineralization (tissue-nonspecific alkaline phosphatase
N C W Mackenzie et al.
Bone, 51(5), 961-968 (2012-07-31)
The recent elucidation of rare human genetic disorders resulting from mutations in ectonucleotide pyrophosphotase/phosphodiesterase (ENPP1), also known as plasma cell membrane glycoprotein 1 (PC-1), has highlighted the vital importance of this molecule in human health and disease. Generalised arterial calcification
Hongsheng Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20077-20082 (2012-11-22)
Innate-like B-1a cells contribute significantly to circulating natural antibodies and mucosal immunity as well as to immunoregulation. Here we show that these classic functions of B-1a cells segregate between two unique subsets defined by expression of plasma cell alloantigen 1

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