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Merck
CN

P4631

Phosphodiesterase I from Bothrops atrox

Type V, crude dried venom, ≥0.01 unit/mg solid

Synonym(s):

5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase

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About This Item

UNSPSC Code:
41106305
NACRES:
NA.32
EC Number:
232-564-0
MDL number:
EC Number:
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type

Type V

form

crude dried venom

specific activity

≥0.01 unit/mg solid

storage temp.

−20°C

Other Notes

One unit will hydrolyze 1.0 μmole of bis(p-nitrophenyl) phosphate per min at pH 8.8 at 37 °C.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Ronald A Albright et al.
The Journal of biological chemistry, 289(6), 3294-3306 (2013-12-18)
NPP4 is a type I extracellular membrane protein on brain vascular endothelium inducing platelet aggregation via the hydrolysis of Ap3A, whereas NPP1 is a type II extracellular membrane protein principally present on the surface of chondrocytes that regulates tissue mineralization.
José Luis Millán
Calcified tissue international, 93(4), 299-306 (2012-11-28)
Endochondral ossification is a carefully orchestrated process mediated by promoters and inhibitors of mineralization. Phosphatases are implicated, but their identities and functions remain unclear. Mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene cause hypophosphatasia, a heritable form of rickets and
Nancy Côté et al.
European journal of pharmacology, 689(1-3), 139-146 (2012-06-05)
Calcific aortic valve disease is the most common heart valve disorder. So far, there is no medical treatment for calcific aortic valve disease. The expression of ectonucleotidases, which metabolize nucleotides into phosphate products, may influence the calcification of the aortic
Antonella Marucci et al.
Biochimica et biophysica acta, 1833(6), 1388-1395 (2013-03-19)
Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling and action. Understanding the mechanisms underlying ENPP1 expression may help unravel molecular mechanisms of insulin resistance. Recent data suggest a role of ENPP1-3'untraslated region (UTR), in controlling ENPP1 expression. We sought to
Aurora Mejía-Benítez et al.
BMC medical genetics, 14, 21-21 (2013-02-05)
Recent genome wide association studies (GWAS) and previous positional linkage studies have identified more than 50 single nucleotide polymorphisms (SNPs) associated with obesity, mostly in Europeans. We aimed to assess the contribution of some of these SNPs to obesity risk

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