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P4656

Pepsinogen from porcine stomach

Grade I-S, lyophilized powder, ~3,000 units/mg protein (after activation to pepsin at pH 2.0 at 25°C)

Synonym(s):

Pepsinogen from hog stomach

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About This Item

CAS Number:
9001-10-9
UNSPSC Code:
12352202
EC Number:
232-581-3
MDL number:
MFCD00131826

Key Documents

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Product Name

Pepsinogen from porcine stomach, Grade I-S, lyophilized powder, ~3,000 units/mg protein (after activation to pepsin at pH 2.0 at 25°C)

biological source

Porcine stomach

type

Grade I-S

assay

≥85% (biuret)

form

lyophilized powder

specific activity

~3,000 units/mg protein (after activation to pepsin at pH 2.0 at 25°C)

purified by

chromatography

UniProt accession no.

P00791

foreign activity

pepsin, free

storage temp.

2-8°C

Gene Information

pig ... PGA5(396892)

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Analysis Note

Protein determined by biuret.

Biochem/physiol Actions

Pepsinogen is the zymogen of pepsin. It is processed by autocatalytic cleavage of 44 amino acids to generate active pepsin. Serum levels of pepsinogen have been measured to identify gastric cancer risk.

Other Notes

One unit will produce a ΔA280 of 0.001 per min at pH 2.0 at 37 °C, measured as TCA-soluble products, using hemoglobin as substrate. (Final volume = 16 mL. Light path = 1 cm.)

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
069K1609
027K1985
024F8090
082H8065
054K0729

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Masahira Haneda et al.
Journal of gastroenterology and hepatology, 28(1), 78-83 (2012-10-05)
Pepsinogen (PG) method is widely used to identify high risk groups of gastric cancer. It is very useful before Helicobacter pylori eradication, but after eradication the method becomes useless because the PGI, PGII, PGI/II ratios change. Therefore, we aimed to
Kazuhiko Inoue
Nihon rinsho. Japanese journal of clinical medicine, 70(10), 1790-1794 (2012-12-04)
It is considered that Helicobacter pylori (Hp) infection is a requirement of the gastric cancer development, and that the atrophy of gastric mucosa is a high risk group of gastric cancer among Hp infected people. We can judge a super
Akwi W Asombang et al.
The American journal of clinical nutrition, 97(5), 1029-1035 (2013-03-29)
Gastric cancer is increasingly recognized in Zambia. Although nutritional factors contribute to gastric cancer risk, their effect in Zambia is unknown. The objective was to investigate the association between intake of dietary antioxidants, urinary 8-iso prostaglandin F2α (8-iso PGF2α) as
Liying Xue et al.
Tumori, 99(2), 134-138 (2013-06-12)
The role of serum pepsinogen level and Helicobacter pylori infection in esophageal carcinoma remains controversial. It may be a risk or protective factor, or without association with esophageal carcinoma. We prospectively examined associations between serum pepsinogen status, H pylori infection
O Szyszka et al.
Journal of animal science, 90(12), 4308-4318 (2012-06-30)
The changes in behavior associated with a (subclinical) acute and a chronic health challenge were investigated to assess their potential value for the development of an early disease detection system in beef cattle. The hypothesis was that acute challenges would
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