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Merck
CN

P4687

Penicillin G potassium salt

powder, suitable for mouse embryo cell culture

Synonym(s):

Benzylpenicillin potassium salt

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About This Item

Empirical Formula (Hill Notation):
C16H17KN2O4S
CAS Number:
113-98-4
Molecular Weight:
372.48
EC Number:
204-038-0
UNSPSC Code:
12352200
PubChem Substance ID:
329820212
Beilstein/REAXYS Number:
3832841
MDL number:
MFCD00036193

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InChI key

IYNDLOXRXUOGIU-LQDWTQKMSA-M

InChI

1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

SMILES string

[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

form

powder

potency

1440-1680 units per mg

technique(s)

cell culture | embryo: suitable

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

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General description

Chemical structure: β-lactam

Application

Recommended for use in embryo culture at approximaterly 100,000 units/L (60 mg/L). Solutions should be filter sterilized and stored at 2-8 °C for up to 1 week, −20 °C for extended periods. Solutions are stable at 37 °C for 3 days.
Used in cell culture in combination with streptomcyin and other antibiotics.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.
Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

pcodes

P280

Hazard Classifications

Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
037K0714
100K10432
100K10431
095K16811
048H04947

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Muneki Hotomi et al.
PloS one, 8(3), e58124-e58124 (2013-03-14)
The protection against pneumococcal infections provided by currently available pneumococcal polysaccharide conjugate vaccines are restricted to the limited number of the serotypes included in the vaccine. In the present study, we evaluated the distribution of the pneumococcal capsular type and
Tina Lund Leunbach et al.
Ugeskrift for laeger, 175(11), 742-743 (2013-03-14)
A pregnant Caucasian woman with newly diagnosed syphilis in the secondary stage was hospitalized for observation while being treated with penicillin. After one dose of penicillin the foetus was delivered by a caesarean section at gestational age 28 weeks +
William B Lo et al.
Journal of neurosurgery. Pediatrics, 11(2), 205-209 (2012-12-04)
Gemella haemolysans has long been considered a commensal in the human upper respiratory tract. Commensals are natural inhabitants on or within another organism, deriving benefit without harming or benefiting the host. Opportunistic infection of the CNS by the species is
Vasim Ahmed et al.
Journal of biotechnology, 163(4), 419-424 (2013-01-12)
In the present study, a novel strategy was adopted to synthesize, β lactamase resistant penicillin G molecules by using the unique properties of silver nanoparticles. Ascorbic acid-stabilized spherical monodispersed silver nanoparticles were prepared by a simple chemical reaction. The formation
Jin-Long Yang et al.
Biofouling, 29(3), 247-259 (2013-03-05)
The effects of bacterial biofilms (BFs) on larval settlement and metamorphosis of the mussel, Mytilus coruscus, were investigated in the laboratory. Of nine different isolates, Shewanella sp.1 BF induced the highest percentage of larval settlement and metamorphosis, whereas seven other
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