P5173
pGlu-3-Methyl-His-Pro Amide
≥97% (HPLC)
Synonym(s):
(His[T-Me])-TRH, [3-Methyl-His2]-Thyrotropin releasing hormone
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About This Item
Empirical Formula (Hill Notation):
C17H24N6O4
CAS Number:
Molecular Weight:
376.41
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Biochem/physiol Actions
Analog of thyrotropin releasing hormone (TRH) that is ten-times more potent than TRH in releasing thyrotropin (TSH) from the anterior pituitary.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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G Vita et al.
Experimental brain research, 83(2), 381-384 (1991-01-01)
The autoradiographic localization of thyrotropin-releasing hormone (TRH) receptors was investigated in the rat spinal cord after transection at the level of T8-T9. The discrete distribution of [3H]-MeTRH binding was measured with a computerized image analyzer at the cervical (C6-C7) and
Modulation of GABAA receptor channels and calcium currents in cultured porcine melanotrophs.
R Schlichter et al.
Annals of the New York Academy of Sciences, 680, 199-210 (1993-05-31)
Michael C Veronesi et al.
Brain research, 1128(1), 79-85 (2006-11-28)
TRH has been found to be efficacious in treating certain neurodegenerative disorders such as epilepsy, Alzheimer's disease, neurotrauma and depression, however, its mechanism of action is poorly understood. Since glutamate (Glu) toxicity has been implicated in these disorders, we utilized