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P5177

Sigma-Aldrich

Methyl palmitate

≥99% (capillary GC)

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Synonym(s):
n-Hexadecanoic acid methyl ester, Methyl hexadecanoate, Palmitic acid methyl ester
Linear Formula:
CH3(CH2)14CO2CH3
CAS Number:
112-39-0
Molecular Weight:
270.45
Beilstein:
1780973
EC Number:
203-966-3
MDL number:
MFCD00008994
PubChem Substance ID:
24898607
NACRES:
NA.25

biological source

plant (palm)

Quality Level

100

Assay

≥99% (capillary GC)

form

solid

refractive index

n20/D 1.4512 (lit.)

bp

185 °C/10 mmHg (lit.)

mp

32-35 °C (lit.)

density

0.852 g/mL at 25 °C (lit.)

functional group

ester

lipid type

saturated FAs

shipped in

ambient

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCCCCCC(=O)OC

InChI

1S/C17H34O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19-2/h3-16H2,1-2H3

InChI key

FLIACVVOZYBSBS-UHFFFAOYSA-N

Gene Information

human ... CNR1(1268) , CNR2(1269)
rat ... Faah(29347)

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General description

Methyl palmitate (PAME), a fatty acid ester of palmitic acid, is a muscurinic receptors antagonist. Methyl palmitate functions as a vasodilator and relaxes the arterioles in retina upon electrical depolarization. In the superior cervical ganglion, methyl palmitate modulates nicotinic receptor. Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. PAME activates Kv7 channels and promotes perivascular adipose tissue.

Application

Methyl palmitate has been used to test impact of cerebral blood flow using laser doppler flowmetry (LDF) experiments and as a standard to determine retention indices (RIs) using gas chromatograph−mass spectrometer

Biochem/physiol Actions

Methyl palmitate has anti-inflammatory and anti-fibrotic effect. Methyl palmitate prevents bleomycin-induced lung inflammation and fibrosis in rats, by inhibiting NF-κB . Methyl palmitate also prevents CCl4-induced liver fibrosis linked to reduced TGF-β .

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest
Lee RHC, et al.
Prostaglandins, Leukotrienes, and Essential Fatty Acids (2018)
Jiao Liu et al.
Biotechnology for biofuels, 8, 229-229 (2016-01-01)
Fatty acid composition is an important physiological parameter of microalgae, which is taken as the third generation alternative resource of biodiesel. To boost microalgal research and applications, a convenient, rapid, and acid-catalyzed transesterification procedure that satisfies the demand for the
Terminal double bonds in the alkenes and acetates of defensive secretion from the thrips Suocerathrips linguis Mound & Marullo, 1994 (Thysanoptera: Phlaeothripidae)
Gehlsen U, et al.
Chemoecology, 19(2), 97-102 (2009)
Palmitic acid methyl ester and its relation to control of tone of human visceral arteries and rat aortas by perivascular adipose tissue
Wang N, et al.
Frontiers in Physiology, 9 (2018)
Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion
Lin HW, et al.
Proceedings of the National Academy of Sciences of the USA, 1051(49), 19526-19531 (2008)
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