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P5679

3-Propylxanthine

≥99%, solid

Synonym(s):

Enprofylline

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About This Item

Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
41078-02-8
Molecular Weight:
194.19
PubChem Substance ID:
24277687
UNSPSC Code:
12352200
EC Number:
255-201-8
MDL number:
MFCD00043205
Beilstein/REAXYS Number:
1116213
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assay

≥99%

form

solid

color

white

solubility

DMSO: soluble, H2O: slightly soluble (Solutions should be stored at 4°C.), alcohol: soluble (Solutions should be stored at 4°C.)

SMILES string

CCCN1C(=O)NC(=O)c2[nH]cnc12

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Biochem/physiol Actions

Weak competitive antagonist at both A1 and A2 adenosine receptors.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122H2503
113K4702
110K4702
097H46374
097H46371

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T Kuzuya et al.
Biological & pharmaceutical bulletin, 20(10), 1051-1055 (1997-11-14)
The pharmacokinetic characteristics, peritoneal permeability and hydrophobicity of three xanthine derivatives, theophylline, enprofylline and 1-methyl-3-propylxanthine (MPX), were investigated in rats. Isotonic saline (30 ml) containing xanthine (2.5, 5 and 10 mg/kg) and blue dextran (0.2%) was administered intraperitoneally. The pharmacokinetic
Carmen Diniz et al.
European journal of pharmacology, 460(2-3), 191-199 (2003-02-01)
Adenosine receptors involved in modulation of contractions were characterized in the bisected rat vas deferens by combining pharmacological and immunohistochemical approaches. In both portions, noradrenaline-elicited contractions were enhanced by the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA), and inhibited by the
D Ukena et al.
European journal of pharmacology, 117(1), 25-33 (1985-10-29)
The effects of enprofylline were studied on A1 adenosine receptors of rat fat cells and on A2 adenosine receptors of human platelets and of guinea-pig lung. Enprofylline antagonized the 5'-N-ethylcarboxamidoadenosine (NECA)-induced stimulation of platelet adenylate cyclase activity with a KB
P Nieri et al.
British journal of pharmacology, 134(4), 745-752 (2001-10-19)
1. Adenosine produced a biphasic lowering of the mean BP with a drastic bradycardic effect at the highest doses. The first phase hypotensive response was significantly reduced by the nitric oxide (NO) synthase inhibitor L-NAME. 2. The A(2a)/A(2b) agonist NECA
Adenosine and adenosine antagonism in asthma.
C Persson
Thorax, 53(5), 437-438 (1998-08-26)
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