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Merck
CN

P5748

Anti-Parkin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-PARK2, Anti-PRKN, Anti-PRKN2, Anti-Parkinson disease protein 2, Anti-Parkinson juvenile disease protein 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02263896
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
10

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry: 1 μg/mL using pedunculopontine tegmental nucleus in rat brain, western blot: 0.5 μg/mL using recombinant human parkin

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... PARK2(5071)
mouse ... Park2(50873)
rat ... Park2(56816)

General description

Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains, that is, RING0, RING1, in between ring (IBR) and RING2. Parkin is a 465 amino acid protein which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.

Immunogen

synthetic peptide CI(298)KELHHFRILGEEQYN(313), corresponding to amino acid residues 298-313 from human parkin. The sequence is completely conserved between human, mouse, and rat.

Application

Anti-Parkin antibody produced in rabbit has been used in Western blotting and immunohistochemistry.

Biochem/physiol Actions

The expression of parkin RBR E3 ubiquitin protein ligase has been found to be altered in various malignancies. Mutations in the gene encoding it have been linked to autosomal recessive juvenile Parkinson (ARJP) disease. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation.

Physical form

Solution of 100 μg (1 mg/mL) in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

常规特殊物品
含少量动物源组分生物产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCM1995
SLBV2579
SLBS3678
SLBL7290V
SLBK5279V

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Xiangnan Zhang et al.
Autophagy, 9(9), 1321-1333 (2013-06-27)
Cerebral ischemia-reperfusion (I-R) is a complex pathological process. Although autophagy can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its contribution to the fate of neurons remains largely unknown. In the present investigation, we found
PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus.
Al-Qahtani AA
Annals of Hepatology (2016)
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance
Xiangnan Zhang
Autophagy (2013)
Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury
Xiangnan Z
Autophagy (2014)
A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.
Biswas R
Gene (2017)
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