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Merck
CN

P6410

Pancreatic Polypeptide rat

≥95% (HPLC)

Synonym(s):

Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp-Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

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About This Item

Empirical Formula (Hill Notation):
C195H298N58O57S
CAS Number:
Molecular Weight:
4398.87
UNSPSC Code:
12352200
MDL number:
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assay

≥95% (HPLC)

UniProt accession no.

application(s)

cell analysis

storage temp.

−20°C

Gene Information

rat ... Ppy(24677)

Biochem/physiol Actions

Agonist at Y4 neuropeptide Y receptors.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Helen M Cox
Autonomic neuroscience : basic & clinical, 133(1), 76-85 (2006-12-05)
This paper reviews the cellular localisation, mechanisms of release and intestinal absorptive actions of neuropeptide Y and its related peptides, peptide YY, pancreatic polypeptide and major fragments NPY(3-36) and PYY(3-36). While NPY is commonly found in inhibitory enteric neurons that
Amanda Sainsbury et al.
Neuropeptides, 44(3), 261-268 (2010-02-02)
Gut-derived peptides are known to regulate food intake by activating specific receptors in the brain, but the target nuclei and neurons influenced are largely unknown. Here we show that peripherally administered pancreatic polypeptide (PP) stimulates neurons in key nuclei of
Shu Lin et al.
PloS one, 4(12), e8488-e8488 (2009-12-31)
Pancreatic polypeptide (PP) is a potent anti-obesity agent known to inhibit food intake in the absence of nausea, but the mechanism behind this process is unknown. Here we demonstrate that in response to i.p. injection of PP in wild type
Ryuichi Moriya et al.
European journal of pharmacology, 627(1-3), 258-264 (2009-10-13)
Pancreatic polypeptide is released mainly from the pancreas, and is thought to be one of the major endogenous agonists of the neuropeptide Y Y(4) receptor. Pancreatic polypeptide has been shown to stimulate colonic muscle contraction, but whether pancreatic polypeptide has
M S Parker et al.
Peptides, 32(2), 258-265 (2010-12-04)
Non-specific binding of Y receptor agonists to intact CHO cells, and to CHO cell or rat brain particulates, is much greater for human neuropeptide Y (hNPY) compared to porcine peptide Y (pPYY), and especially relative to human pancreatic polypeptide (hPP).

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