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Merck
CN

P6490

PGP-4008

Synonym(s):

N-(1-Benzyl-2,3-dihydro-1H-pyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide

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About This Item

Empirical Formula (Hill Notation):
C26H23N3O
CAS Number:
365565-02-2
Molecular Weight:
393.48
NACRES:
NA.77
PubChem Substance ID:
329820244
UNSPSC Code:
12161501
MDL number:
MFCD03452998

Key Documents

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InChI key

HVIAKQBMYMKWII-UHFFFAOYSA-N

SMILES string

O=C(Cc1ccccc1)Nc2c3CCN(Cc4ccccc4)c3nc5ccccc25

InChI

1S/C26H23N3O/c30-24(17-19-9-3-1-4-10-19)28-25-21-13-7-8-14-23(21)27-26-22(25)15-16-29(26)18-20-11-5-2-6-12-20/h1-14H,15-18H2,(H,27,28,30)

assay

≥90% (TLC)

form

powder

storage temp.

−20°C

Quality Level

200

Application

Selectively inhibits P-glycoprotein.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBG4670V
SLBD4452V
SLBB9116V
090M1365
069K1297

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C D Smith et al.
Oncology research, 12(5), 219-229 (2001-06-22)
Tumor cells often develop drug resistance through overexpression of membrane transport proteins that effectively efflux anticancer agents. The pharmacologies of the two best-studied transporters, P-glycoprotein (Pgp) and MRP1, are partially overlapping but distinct. To improve the therapeutic potential of drug

Articles

Protein-based Drug Transport

Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.

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