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Merck
CN

P7081

Sigma-Aldrich

1,2-Didecanoyl-sn-glycero-3-phosphocholine

≥99% (TLC)

Synonym(s):

PC, (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxodecyl)oxy]-3,5,9-trioxa-4-phosphanonadecan-1-aminium 4-oxide, inner salt, 1,2-Dicaprinoyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1,2-didecanoyl, L-α-Phosphatidylcholine, didecanoyl, Didecanoyllecithin, PC(10:0/10:0)

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About This Item

Empirical Formula (Hill Notation):
C28H56NO8P
CAS Number:
3436-44-0
Molecular Weight:
565.72
Beilstein:
3757665
MDL number:
MFCD00063538
UNSPSC Code:
51191904
PubChem Substance ID:
24898817

Key Documents

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Assay

≥99% (TLC)

form

powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O)=O

InChI

1S/C28H56NO8P/c1-6-8-10-12-14-16-18-20-27(30)34-24-26(25-36-38(32,33)35-23-22-29(3,4)5)37-28(31)21-19-17-15-13-11-9-7-2/h26H,6-25H2,1-5H3/t26-/m1/s1

InChI key

MLKLDGSYMHFAOC-AREMUKBSSA-N

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
120M5222V
120M5222
029K5206
064K5210
055H8377

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C Agerholm et al.
Journal of pharmaceutical sciences, 83(12), 1706-1711 (1994-12-01)
The transepithelial transport of biosynthetic human growth hormone (hGH) formulated with the absorption enhancers didecanoyl-L-alpha-phosphatidylcholine (DDPC) and alpha-cyclodextrin (alpha-CD) was studied after intranasal administration to rabbits. Plasma concentrations of the hormone were determined until 240 min post administration by ELISA
Vivek S Purohit et al.
The AAPS journal, 8(2), E362-E370 (2006-06-27)
Replacement therapy with exogenous recombinant factor VIII (rFVIII) to control bleeding episodes results in the development of inhibitory antibodies in 15% to 30% of hemophilia A patients. The inhibitory antibodies are mainly directed against specific and universal immunodominant epitopes located
C Vermehren et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(9), 1083-1088 (1997-10-06)
The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and the metabolism of 1,2-di[1-14C]decanoyl-L-3-phosphatidylcholine and 1,2-didecanoyl-L-3-phosphatidyl[N-methyl-3H]choline in rabbit nasal mucosa in vivo. One minute after nasal application of DDPC, 4.4-7.5%
Effect of absorption enhancers on ciliated epithelium: a novel in vivo toxicity screening method using rotifers.
E Adriaens et al.
Pharmaceutical research, 14(4), 541-545 (1997-04-01)
Qunfeng Zhang et al.
Tree physiology, 41(2), 317-330 (2020-10-27)
It is well known that green tea made from fully developed leaves located at the base of young shoots is of lower quality than that made from the still developing leaves located on the top of the shoot. It has
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