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Merck
CN

P7291

Anti-Thromboxane B2 antibody produced in rabbit

whole antiserum, lyophilized powder

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
RIA
Citations:
4
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

contains

0.01% sodium azide

species reactivity

human

technique(s)

radioimmunoassay: suitable

UniProt accession no.

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PTGS1(5742)

General description

Prostaglandin G/H synthase 1 (PTGS1)/Cyclooxygenase-1 (COX-1) is an enzyme that is expressed in the stomach, kidney and platelets. This gene is located on human chromosome 9q32−q33.3 and has 11 exons.

Immunogen

thromboxane B2-BSA.

Biochem/physiol Actions

Cyclooxygenase-1 (COX-1/PTGS1) helps to convert arachidonic acid to prostaglandin H2. It plays an important role in inflammation, pain, arthritic disease and cancer. PTGS1 helps to maintain renal blood flow and modulates platelet aggregation. It also protects gastric mucosa.

Physical form

The product is provided as a pre-diluted antiserum that has been lyophilized from a solution containing 0.01% sodium azide as a preservative.

Preparation Note

For a working dilution of 1:10, reconstitute with 5 mL buffer containing 0.01 M phosphate buffered saline, pH 7.4, 0.1% bovine serum albumin, and 0.1% sodium azide.
Prior to reconstitution, store at 2-8 °C.
After reconstitution:
1. Stock Solution: Separate into aliquots and freeze. Repeated freezing and thawing is not recommended
2. Working Solution: Discard if unused within 12 hours.

Analysis Note

Tests per vial and specificity are determined using a dextran coated charcoal radioimmunoassay (RIA).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品

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Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1)
Lee CR, et al.
Pharmacogenetics and Genomics, 17(2), 145-145 (2007)
Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling
Wang Y, et al.
Stem Cell Research & Therapy, 10(1), 1-10 (2019)
T Mahmud et al.
Gut, 43(6), 775-782 (1998-11-21)
Non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage by a non-prostaglandin (PG) dependent "topical" action and by inhibiting cyclooxygenase. To discriminate between these two effects by studying some key pathophysiological steps in NSAID enteropathy following administration of (R)- and (S)-flurbiprofen, the



Global Trade Item Number

SKUGTIN
P7291-100TST04061833621899