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Merck
CN

P7674

Sigma-Aldrich

Pyrantel (+)-tartrate salt

Synonym(s):

1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine

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About This Item

Empirical Formula (Hill Notation):
C11H14N2S · C4H6O6
CAS Number:
33401-94-4
Molecular Weight:
356.39
EC Number:
251-501-8
MDL number:
MFCD00216022
UNSPSC Code:
51101500
PubChem Substance ID:
329820314

Key Documents

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solubility

H2O: 4.0 mL, clear, colorless to faint yellow or tan (Solvent: 200 mg plus 4.0 mL )

antibiotic activity spectrum

parasites

Mode of action

enzyme | inhibits

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CCCN=C1\C=C\c2cccs2

InChI

1S/C11H14N2S.C4H6O6/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10;5-1(3(7)8)2(6)4(9)10/h2,4-6,9H,3,7-8H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/b6-5+;/t;1-,2-/m.1/s1

InChI key

VWRCYAZJKNPEQR-NIEARKAZSA-N

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Application

Pyrantel is used to study neuronal nicotinic receptors and has been is used to treat parasiticinfections in livestock. Pyrantel tartrate salt is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs).

Biochem/physiol Actions

Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. Cholinesterase inhibitor.
Pyrantel is a nematode muscle cell-associated nicotinic agonist for the acetylcholine (ACh) receptor. This is a cholinesterase inhibitor. It causes spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors.

Other Notes

Keep container tightly closed in a dry and well-ventilated place

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
079F0937V
079F0937

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V A Thorpe
Journal of chromatographic science, 26(11), 545-550 (1988-11-01)
Carbadox (CBX), an antibacterial agent, and pyrantel tartrate (PT), an anthelmintic, are formulated either separately or together in swine feeds. The official Association of Official Analytical Chemists (AOAC) spectrophotometric methods for both drugs are long, nonspecific, and require standard addition
[Evaluation of the effectiveness of Banminth in the treatment of ascaridiasis and Capillaria infection in birds].
A Latała et al.
Wiadomosci parazytologiczne, 33(3), 377-382 (1987-01-01)
[Use of small doses of pyrantel tartrate in the treatment of ascaridiasis in laying hens].
A Fagasiński
Wiadomosci parazytologiczne, 33(3), 373-376 (1987-01-01)
E A Kruttlin et al.
Veterinary therapeutics : research in applied veterinary medicine, 2(3), 268-276 (2001-07-01)
Sarcocystis neurona is the etiologic agent of equine protozoal myeloencephalitis, a neurologic disease of horses. The present study was designed to test the hypothesis that pyrantel tartrate can kill S. neurona merozoites growing in equine dermal cell culture. Sarcocystis neurona
R A Valdez et al.
Veterinary parasitology, 60(1-2), 83-102 (1995-11-01)
The bioequivalence of Strongid C and generic pyrantel tartrate was determined in a controlled study using 30 horses with naturally acquired endoparasitic infections. Three horses were randomly allocated to each of ten replicates based on quantitative nematode and ascarid egg
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