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Merck
CN

P7842

Prepro-Thyrotropin Releasing Hormone Fragment 178-199

Synonym(s):

CRIF, Corticotropin release inhibiting factor

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About This Item

Empirical Formula (Hill Notation):
C116H176N28O39S
CAS Number:
122018-92-2
Molecular Weight:
2618.87
UNSPSC Code:
12352200
MDL number:
MFCD00080148

Key Documents

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SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCC(O)=O)C(O)=O

storage temp.

−20°C

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
101K1995
057H1217
021K1403
021K14031

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T Mitsuma et al.
Endocrine regulations, 27(2), 49-55 (1993-06-01)
The effect of dexamethasone administration on the concentration of thyrotropin releasing hormone (TRH) and pre-pro-TRH connecting peptides TRH-glycine (TRH-Gly), and pre-pro-TRH (178-199) in various rat organs was studied. Three groups of 35 rats each were injected dexamethasone (Group A: 25
K Valentijn et al.
Brain research. Molecular brain research, 14(3), 221-230 (1992-07-01)
The rat thyrotropin-releasing hormone (TRH) precursor (prepro-TRH) contains five copies of the TRH progenitor sequence linked together by intervening sequences. Recently, we have shown that the connecting peptides prepro-TRH-(160-169) (Ps4) and prepro-TRH-(178-199) (Ps5) are released from rat hypothalamic neurones in
The corticotropin-release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis.
D Engler et al.
Endocrine reviews, 20(4), 460-500 (1999-08-24)
E Redei et al.
Endocrinology, 136(8), 3557-3563 (1995-08-01)
ACTH is the major regulator of the body's adaptive response to stress and the physiological stimulus for glucocorticoid secretion. In addition to the known negative feedback regulation of ACTH by glucocorticoids, a hypothalamic corticotropin release-inhibiting factor (CRIF) that inhibits ACTH
R F McGivern et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(12), 4886-4894 (1997-06-15)
A corticotropin release-inhibiting factor (CRIF) in brain has been postulated for several decades, based on increased plasma levels of ACTH and corticosterone after hypothalamic-pituitary disconnection. Recent in vitro studies indicate that prepro-TRH178-199 may function as an endogenous CRIF, prompting us
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