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Merck
CN

P7897

Peruvoside from Thevetia neriifolia

~90%, powder

Synonym(s):

(3β,5β)-3-(6-Deoxy-3-O-methyl-α-L-glucopyranosyl]oxyl)-14-hydroxy-19-oxocard-20(22)-enolide

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About This Item

Empirical Formula (Hill Notation):
C30H44O9
CAS Number:
1182-87-2
Molecular Weight:
548.66
UNSPSC Code:
12352200
PubChem Substance ID:
24898887
EC Number:
214-659-9
MDL number:
MFCD00133752

Key Documents

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InChI key

PMTSPAGBAFCORP-UHFFFAOYSA-N

InChI

1S/C30H44O9/c1-16-24(33)26(36-3)25(34)27(38-16)39-19-6-10-29(15-31)18(13-19)4-5-22-21(29)7-9-28(2)20(8-11-30(22,28)35)17-12-23(32)37-14-17/h12,15-16,18-22,24-27,33-35H,4-11,13-14H2,1-3H3

SMILES string

COC1C(O)C(C)OC(OC2CCC3(C=O)C(CCC4C3CCC5(C)C(CCC45O)C6=CC(=O)OC6)C2)C1O

assay

~90%

form

powder

color

light yellow

storage temp.

2-8°C

Biochem/physiol Actions

Cardiac glycoside with the same inotropic and chronotropic effects on heart function as ouabain.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
040H0048

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T K Bose et al.
Journal of the Indian Medical Association, 97(10), 407-410 (2000-01-19)
Yellow oleander (Thevetia neriifolia) is a commonly grown tree found widely in Eastern India. The seeds of yellow oleander are highly poisonous and contain three glycosides--thevetin, thevetoxin and peruvoside. Yellow oleander seed ingestion is usually with suicidal intent in Eastern
B Fierro et al.
Italian journal of neurological sciences, 8(2), 167-169 (1987-04-01)
The case of a myasthenia-like syndrome induced by cardiovascular drugs is reported. The clinical and electrophysiological features of the case are discussed.
[Hemodynamic studies on the effects of peruvoside on congestive heart failure].
F Gu et al.
Zhonghua xin xue guan bing za zhi, 20(3), 157-159 (1992-06-01)
Yellow oleander poisoning.
A Misra
The Journal of the Association of Physicians of India, 39(3), 295-295 (1991-03-01)
Hairi Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(12), 4609-4614 (2012-03-08)
The advent of powerful genomics technologies has uncovered many fundamental aspects of biology, including the mechanisms of cancer; however, it has not been appropriately matched by the development of global approaches to discover new medicines against human diseases. Here we
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