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About This Item
Linear Formula:
C3H5O4PCa
CAS Number:
Molecular Weight:
176.12
EC Number:
MDL number:
UNSPSC Code:
51101500
PubChem Substance ID:
solubility
1 M HCl: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Ca++].CC1OC1P([O-])([O-])=O
InChI
1S/C3H7O4P.Ca/c1-2-3(7-2)8(4,5)6;/h2-3H,1H3,(H2,4,5,6);/q;+2/p-2
InChI key
YMZJBJPWTXJQMR-UHFFFAOYSA-L
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Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used to study resistance proteins in Bacillus subtilis and Mycobacterium tuberculosis. It is a potential treatment for bronchiectasis.
Biochem/physiol Actions
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
Phosphomycin calcium salt blocks the formation or N-acetylmuramic acid by inhibiting UDP-Nacetylglucosamine 3-enolpyruvate transferase (MurA).
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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