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P7903

Pipemidic acid

Synonym(s):

8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C14H17N5O3
CAS Number:
51940-44-4
Molecular Weight:
303.32
NACRES:
NA.85
PubChem Substance ID:
24898889
UNSPSC Code:
51282938
EC Number:
257-530-2
MDL number:
MFCD00057291
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form

powder

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, cell wall synthesis | interferes, enzyme | inhibits

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3

InChI

1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)

InChI key

JOHZPMXAZQZXHR-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

General description

Chemical structure: quinolone

Application

Pipemidic acid is used to study DNA damage and mutagenic activity. It has been used to induce articular lesions in the neonatal mouse and is used to study human lymphocyte blastogenesis and γ-interferon production .

Biochem/physiol Actions

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis.

Analysis Note

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Other Notes

10g,100g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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