P8087
Monoclonal Anti-Plakoglobin (Catenin γ) antibody produced in mouse
clone 15F11, ascites fluid, buffered aqueous solution
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Conjugate:
unconjugated
Clone:
15F11, monoclonal
Application:
ARR, ICC, IF, IHC (f), IP, WB
Citations:
16
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
15F11, monoclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
contains
15 mM sodium azide
species reactivity
bovine, canine, human
technique(s)
immunocytochemistry: suitable using cultured cells, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect immunofluorescence: 1:1,000 using cultured MDBK cells, microarray: suitable, western blot: 1:2,000 using cultured MDBK cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... JUP(3728)
General description
Plakoglobin is a desmosomal protein that regulates developmental signalling in vertebrates. Tyrosine phosphorylation of plakoglobin has been linked to adenocarcinomas . Plakoglobin may function as a tumor suppressor in ovarian and breast cancers .
Immunogen
recombinant chicken plakoglobin.
Application
Monoclonal anti-plakoglobin (catenin γ) antibody is suitable for use in immunocytochemistry (using MDCK cells), immunoprecipitation, and in immunoblotting . The antibody may also be used for immunohistochemistry (frozen sections), microarray, western blot (1:500, using cultured MDBK cells) and indirect immunofluorescence (1:1000, using cultured MDBK cells).
Biochem/physiol Actions
The antibody recognizes the plakoglobin (catenin-γ) molecule (85 kDa and possibly a slightly lower band) by immunoblotting. It does not cross-react with β-catenin. The antibody reacts with plakoglobin in bovines, humans and dogs, but does not react with β catenin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
动物来源生物产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
S Shibamoto et al.
Cell adhesion and communication, 1(4), 295-305 (1994-01-01)
The effect of hepatocyte growth factor/scatter factor (HGF/SF) and epidermal growth factor (EGF) on cadherin-mediated adhesion of human carcinoma cells was studied. HGF/SF induced scattering of colonic adenocarcinoma HT29 and gastric adenocarcinomas MKN7 and MKN74 cells. Likewise, EGF induced scattering
Rene L Begay et al.
JACC. Clinical electrophysiology, 4(4), 504-514 (2018-08-02)
The purpose of this study was to assess the phenotype of Filamin C (FLNC) truncating variants in dilated cardiomyopathy (DCM) and understand the mechanism leading to an arrhythmogenic phenotype. Mutations in FLNC are known to lead to skeletal myopathies, which
Iris Wu et al.
Communications medicine, 4(1), 38-38 (2024-03-19)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause of this disease, representing a significant
Zhilun Li et al.
Molecular biology of the cell, 21(19), 3317-3329 (2010-08-20)
Cell-to-extracellular matrix adhesion is regulated by a multitude of pathways initiated distally to the core cell-matrix adhesion machinery, such as via growth factor signaling. In contrast to these extrinsically sourced pathways, we now identify a regulatory pathway that is intrinsic
H Aberle et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(14), 6384-6388 (1995-07-03)
The gene encoding human plakoglobin was mapped to chromosome 17q12-q22. An intragenic restriction fragment length polymorphism was used to localize the plakoglobin gene distal to locus KRT10 and proximal to the marker D17S858. The plakoglobin gene colocalizes with the polymorphic
Related Content
Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P8087-.2ML | 04061837873546 |
| P8087-100UL | 04061837873553 |
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service