P8227
1,3-PBIT dihydrobromide
Synonym(s):
Phenylene-1,3-bis(ethane-2-isothiourea) dihydrobromide
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About This Item
Empirical Formula (Hill Notation):
C12H18N4S2 · 2HBr
Molecular Weight:
444.25
UNSPSC Code:
12352200
PubChem Substance ID:
SMILES string
Br.Br.NC(=N)SCCc1cccc(CCSC(N)=N)c1
storage temp.
−20°C
Gene Information
human ... NOS2(4843), NOS3(4846)
Biochem/physiol Actions
Potent inducible NOS (iNOS) inhibitor, Ki = 47 nM; endothelial NOS (eNOS) inhibitor Ki = 9 μM.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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E P Garvey et al.
The Journal of biological chemistry, 269(43), 26669-26676 (1994-10-28)
S-Ethylisothiourea was a potent competitive inhibitor of human nitric oxide synthase (NOS), with Ki values of 17, 36, and 29 nM for the inducible (i), endothelial (e), and neuronal (n) isozymes, respectively. Unlike some potent inhibitors of NOS, no time
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