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Merck
CN

P8582

Podophyllin from Podophyllum emodii

powder

Synonym(s):

Podophyllum resin

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About This Item

CAS Number:
9000-55-9
NACRES:
NA.83
UNSPSC Code:
12352204
EC Number:
232-546-2
MDL number:
MFCD00131926
Form:
powder

Key Documents

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InChI key

KOUZYZCESNTXJO-UHFFFAOYSA-N

InChI

1S/2C22H24O9.2C22H22O8/c2*1-27-16-4-10(5-17(28-2)21(16)29-3)18-11-6-14-15(31-9-30-14)7-12(11)20(24)13(8-23)19(18)22(25)26;2*1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h2*4-7,13,18-20,23-24H,8-9H2,1-3H3,(H,25,26);2*4-7,13,18-20,23H,8-9H2,1-3H3

form

powder

color

brown

storage temp.

2-8°C

General description

Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker.

Biochem/physiol Actions

Podophyllin is used to treat condylomata acuminate, a type of venereal warts. It exhibit several biological functions and is mainly used in the treatment of constipation, hepatic disorder and rheumatic arthritis.

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Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
038F11041V
038F11041

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Simultaneous determination of podophyllotoxin, quercetin and kaempferol in podophyllin by liquid chromatography tandem mass spectrometry
Lin M C, et al.
Journal of food and drug analysis, 16(6), 251-251 (2008)
Podophyllin and its use in the treatment of condylomata acuminata
Sundharam J A, et al.
Indian Journal of Dermatology, Venereology and Leprology, 56(1), 10-10 (1990)
Condylomata acuminata: two hundred cases treated with podophyllin
Culp OS and Kaplan IW
Annals of Surgery, 120(2), 251-251 (1944)
Amy L Lane et al.
Phytochemistry, 67(12), 1224-1231 (2006-06-24)
Vascular plants produce a variety of molecules of phenylpropanoid biosynthetic origin, including lignoids. Recent investigations indicated that in freshwater plants, some of these natural products function as chemical defenses against generalist consumers such as crayfish. Certain structural features are shared
Hugo McClean et al.
International journal of STD & AIDS, 16(3), 212-216 (2005-04-15)
This was a cross-sectional survey that collected data relating to management of anogenital warts (AGW) during a single-patient visit only at genitourinary medicine clinics. Single-agent use of cryotherapy, podophyllotoxin and trichloroacetic acid (TCA) were the most common treatment modalities, accounting
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