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Merck
CN

P8780

Phorbol 12-retinoate 13-acetate

≥95%, powder

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About This Item

Empirical Formula (Hill Notation):
C42H56O8
CAS Number:
80188-99-4
Molecular Weight:
688.89
PubChem Substance ID:
24898977
UNSPSC Code:
12352200

Key Documents

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InChI

1S/C42H56O8/c1-24(16-17-31-26(3)15-12-18-38(31,7)8)13-11-14-25(2)19-34(45)49-37-28(5)41(48)32(35-39(9,10)42(35,37)50-29(6)44)21-30(23-43)22-40(47)33(41)20-27(4)36(40)46/h11,13-14,16-17,19-21,28,32-33,35,37,43,47-48H,12,15,18,22-23H2,1-10H3/b14-11+,17-16+,24-13+,25-19+/t28-,32+,33-,35-,37-,40-,41-,42-/m1/s1

InChI key

GTNCUWBKHZZECN-IXTPSRJDSA-N

SMILES string

CC1C(OC(=O)\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)CCCC2(C)C)C3(OC(C)=O)C(C4C=C(CO)CC5(O)C(C=C(C)C5=O)C14O)C3(C)C

assay

≥95%

form

powder

color

yellow

storage temp.

−20°C

Biochem/physiol Actions

Skin tumor promoter.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
065H0662

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Kumiko Tanabe et al.
Journal of neurochemistry, 106(2), 519-528 (2008-04-04)
Dexmedetomidine (Dexmd), a potent and highly specific alpha(2) adrenoreceptor agonist, is an efficient therapeutic agent for sedation. Dexmd has been recently reported to have a neuroprotective effect. Heat shock protein (HSP) 27, a low-molecular weight HSP has been shown to
S Rajagopal et al.
Neuroscience, 159(2), 618-628 (2009-01-27)
Ca(v)2.2 high voltage-gated calcium channels are regulated by phorbol-12-myristae, 13-acetate (PMA) via Ser/Thr protein kinase C (PKC) phosphorylation sites in the I-II linker and C-terminus of the alpha(1) 2.2 subunit. Here we show that PMA enhancement of Ca(v)2.2 currents expressed
Ying Fan et al.
Neuroscience bulletin, 25(4), 187-195 (2009-07-28)
The present study aims to investigate the role of protein kinase C delta subtype (PKCdelta) phosphorylation in the process of 6-hydroxydopamine (6-OHDA)-induced dopaminergic cell death, and demonstrate the molecular basis of neurological disorders, such as Parkinson's disease. The pheochromocytoma (PC12)
Ye Yi-zhou et al.
Lipids in health and disease, 11, 168-168 (2012-12-12)
Administration of androgens decreases plasma concentrations of high-density lipid cholesterol (HDL-C). However, the mechanisms by which androgens mediate lipid metabolism remain unknown. This present study used HepG2 cell cultures and ovariectomized C57BL/6 J mice to determine whether apolipoprotein M (ApoM)
Carsten Müller et al.
Journal of medicinal food, 14(1-2), 34-39 (2010-12-07)
Vineatrol®30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a
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