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P8780

Phorbol 12-retinoate 13-acetate

≥95%, powder

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About This Item

Empirical Formula (Hill Notation):
C42H56O8
CAS Number:
80188-99-4
Molecular Weight:
688.89
PubChem Substance ID:
24898977
UNSPSC Code:
12352200
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assay

≥95%

form

powder

color

yellow

storage temp.

−20°C

SMILES string

CC1C(OC(=O)\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)CCCC2(C)C)C3(OC(C)=O)C(C4C=C(CO)CC5(O)C(C=C(C)C5=O)C14O)C3(C)C

InChI

1S/C42H56O8/c1-24(16-17-31-26(3)15-12-18-38(31,7)8)13-11-14-25(2)19-34(45)49-37-28(5)41(48)32(35-39(9,10)42(35,37)50-29(6)44)21-30(23-43)22-40(47)33(41)20-27(4)36(40)46/h11,13-14,16-17,19-21,28,32-33,35,37,43,47-48H,12,15,18,22-23H2,1-10H3/b14-11+,17-16+,24-13+,25-19+/t28-,32+,33-,35-,37-,40-,41-,42-/m1/s1

InChI key

GTNCUWBKHZZECN-IXTPSRJDSA-N

Biochem/physiol Actions

Skin tumor promoter.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
065H0662

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Joanna Homa et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 183(3), 313-322 (2012-09-28)
Due to the specific habitat conditions in which they live, earthworms are constantly exposed to pathogens. Consequently, they have evolved various immuno-defense mechanisms, including cellular (coelomocytes) and humoral responses, which may help to eliminate deleterious micro-organisms but also repair and/or
Lina Ji et al.
Journal of Alzheimer's disease : JAD, 19(3), 829-838 (2010-02-17)
We have previously reported that gelsolin, an actin binding protein, regulates the fibrillization of amyloid-beta protein. We report here that the expression of cytoplasmic gelsolin (cgelsolin) was upregulated in a concentration-dependent manner when SH-SY5Y, PC-12, and HEK-293 cells were subjected
Christina Krabbe et al.
Journal of neurochemistry, 110(6), 1908-1920 (2009-07-25)
Neural stem cells constitute a promising source of cells for transplantation in Parkinson's disease, but a protocol for controlled dopaminergic differentiation is not yet available. Here we investigated the effect of the anti-apoptotic protein Bcl-x(L) and oxygen tension on dopaminergic
Jacob Eriksen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(21), 6794-6808 (2009-05-29)
The dopamine transporter (DAT) mediates reuptake of dopamine from the synaptic cleft and is a target for widely abused psychostimulants such as cocaine and amphetamine. Nonetheless, little is known about the cellular distribution and trafficking of natively expressed DAT. Here
Kumiko Tanabe et al.
Journal of neurochemistry, 106(2), 519-528 (2008-04-04)
Dexmedetomidine (Dexmd), a potent and highly specific alpha(2) adrenoreceptor agonist, is an efficient therapeutic agent for sedation. Dexmd has been recently reported to have a neuroprotective effect. Heat shock protein (HSP) 27, a low-molecular weight HSP has been shown to
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