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Merck
CN

P8780

Sigma-Aldrich

Phorbol 12-retinoate 13-acetate

≥95%, powder

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About This Item

Empirical Formula (Hill Notation):
C42H56O8
CAS Number:
80188-99-4
Molecular Weight:
688.89
UNSPSC Code:
12352200
PubChem Substance ID:
24898977

Key Documents

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Assay

≥95%

form

powder

color

yellow

storage temp.

−20°C

SMILES string

CC1C(OC(=O)\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)CCCC2(C)C)C3(OC(C)=O)C(C4C=C(CO)CC5(O)C(C=C(C)C5=O)C14O)C3(C)C

InChI

1S/C42H56O8/c1-24(16-17-31-26(3)15-12-18-38(31,7)8)13-11-14-25(2)19-34(45)49-37-28(5)41(48)32(35-39(9,10)42(35,37)50-29(6)44)21-30(23-43)22-40(47)33(41)20-27(4)36(40)46/h11,13-14,16-17,19-21,28,32-33,35,37,43,47-48H,12,15,18,22-23H2,1-10H3/b14-11+,17-16+,24-13+,25-19+/t28-,32+,33-,35-,37-,40-,41-,42-/m1/s1

InChI key

GTNCUWBKHZZECN-IXTPSRJDSA-N

Biochem/physiol Actions

Skin tumor promoter.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
065H0662

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Carsten Müller et al.
Journal of medicinal food, 14(1-2), 34-39 (2010-12-07)
Vineatrol®30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a
Ying Fan et al.
Neuroscience bulletin, 25(4), 187-195 (2009-07-28)
The present study aims to investigate the role of protein kinase C delta subtype (PKCdelta) phosphorylation in the process of 6-hydroxydopamine (6-OHDA)-induced dopaminergic cell death, and demonstrate the molecular basis of neurological disorders, such as Parkinson's disease. The pheochromocytoma (PC12)
Ye Yi-zhou et al.
Lipids in health and disease, 11, 168-168 (2012-12-12)
Administration of androgens decreases plasma concentrations of high-density lipid cholesterol (HDL-C). However, the mechanisms by which androgens mediate lipid metabolism remain unknown. This present study used HepG2 cell cultures and ovariectomized C57BL/6 J mice to determine whether apolipoprotein M (ApoM)
Jacob Eriksen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(21), 6794-6808 (2009-05-29)
The dopamine transporter (DAT) mediates reuptake of dopamine from the synaptic cleft and is a target for widely abused psychostimulants such as cocaine and amphetamine. Nonetheless, little is known about the cellular distribution and trafficking of natively expressed DAT. Here
Percy Luu et al.
Journal of neurophysiology, 100(1), 533-538 (2008-05-03)
Long-term potentiation (LTP) of excitatory synapses on ventral tegmental area (VTA) dopamine (DA) cells is thought to play an important role in mediating some of the behavioral effects of drugs of abuse yet little is known about its underlying mechanisms.
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