P9018
Phorbol 12,13-didecanoate
solid
Synonym(s):
PDD, Phorbol 12,13-dicaprinate
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About This Item
Empirical Formula (Hill Notation):
C40H64O8
CAS Number:
Molecular Weight:
672.93
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
6036113
SMILES string
[H][C@@]12C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@]3([H])[C@@]1(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCC)[C@]4(OC(=O)CCCCCCCCC)C2C4(C)C
form
solid
color
white
solubility
DMSO: soluble, ethanol: soluble, methanol: soluble
storage temp.
−20°C
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General description
More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent
Biochem/physiol Actions
Strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes.
Preparation Note
A stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.
Disclaimer
Photosensitive
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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I Magiati et al.
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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 25(1), 67-74 (2014-09-15)
Periodontal disease (PDD) was associated with inflammation, malnutrition, and higher mortality in hemodialysis (HD) patients. Cross-sectional observational study, aiming to assess the prevalence of PDD and the possible relationship among PDD, inflammation, and malnutrition in HD patients. Single HD center
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Schizophrenia bulletin, 41(3), 744-753 (2014-10-22)
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K Hu et al.
The American journal of physiology, 276(2 Pt 2), H488-H495 (1999-02-10)
Both protein kinase C (PKC) and adenosine receptor activation have been shown to enhance ATP-sensitive K+ (KATP) channels. The present studies were designed to determine whether PKC mediates adenosine effects on the KATP channel. The dependence of KATP channel activity
Leandro Francisco S Bastos et al.
European journal of pharmacology, 576(1-3), 171-179 (2007-08-28)
Tetracyclines induce anti-inflammatory effects unrelated to their antimicrobial activities. We investigated the effect induced by minocycline and doxycycline in models of nociceptive and inflammatory pain, edema, fever, cell migration and formation of fibrovascular tissue, as these effects have not been
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