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About This Item
Empirical Formula (Hill Notation):
C8H10NO6P · xH2O
CAS Number:
Molecular Weight:
247.14 (anhydrous basis)
Beilstein:
234749
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.79
biological source
synthetic (organic)
Quality Level
Assay
≥98%
form
powder
technique(s)
HPLC: suitable
color
beige
off-white to yellow
mp
140-143 °C
storage temp.
−20°C
SMILES string
CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
InChI
1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChI key
NGVDGCNFYWLIFO-UHFFFAOYSA-N
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General description
Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.
Application
Pyridoxal 5′-phosphate hydrate has also been used:
- as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)
- in D-amino acid transaminase reaction(10)
- as a cofactor for L-glutamic acid decarboxylase
Biochem/physiol Actions
Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS) cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and D-serine dehydratase.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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