P9799
pGlu-Gly-Arg-Phe amide acetate salt
≥97% (HPLC)
Synonym(s):
Antho-RFamide
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About This Item
Empirical Formula (Hill Notation):
C22H32N8O5
CAS Number:
Molecular Weight:
488.54
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
SMILES string
NC(=N)NCCCC(NC(=O)CNC(=O)C1CCC(=O)N1)C(=O)NC(Cc2ccccc2)C(N)=O
InChI
1S/C22H32N8O5/c23-19(33)16(11-13-5-2-1-3-6-13)30-21(35)14(7-4-10-26-22(24)25)29-18(32)12-27-20(34)15-8-9-17(31)28-15/h1-3,5-6,14-16H,4,7-12H2,(H2,23,33)(H,27,34)(H,28,31)(H,29,32)(H,30,35)(H4,24,25,26)
InChI key
CMWHGNOBFVLNTC-UHFFFAOYSA-N
Gene Information
mouse ... Nts(67405)
Biochem/physiol Actions
May be a neurotransmitter at neuromuscular junctions.
Other Notes
Neuropeptide originally isolated from the pennatulid Renilla koellikeri and the sea anemone Anthopleura elegantissima
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Grimmelikhuijzen, C.J.P. and Gregor, A.
Febs Letters, 211, 105-105 (1987)
C Schmutzler et al.
The Journal of biological chemistry, 267(31), 22534-22541 (1992-11-05)
Neuropeptides are synthesized as large precursor proteins that undergo posttranslational cleavages and modifications to produce bioactive peptides. Here, we have cloned two closely related precursor proteins for the sea anemone neuropeptide Antho-RFamide (<Glu-Gly-Arg-Phe-NH2) from Anthopleura elegantissima. The first precursor (435
M Anctil et al.
General pharmacology, 20(3), 381-384 (1989-01-01)
1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla köllikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5
A Yasuda et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 104(2), 235-240 (1993-02-01)
1. Two carboxyl-terminally amidated peptides (CP1 and CP2) were isolated from the blue crab (Callinectes sapidus) eyestalks by a method of carboxyl-terminal analysis. 2. The peptides were sequenced as pGlu-Gly-Arg-Phe-amide (CP1) and pGlu-Leu-Gly-Arg-Phe-amide (CP2). 3. Each carboxyl-terminus of the peptides
P A Anderson et al.
Cell and tissue research, 267(1), 67-74 (1992-01-01)
The nervous systems of the scyphomedusae Chrysaora hysoscella, Cyanea capillata and Cyanea lamarckii (Phylum Cnidaria) were stained using an anti-serum against the anthozoan neuropeptide Antho-RFamide. Staining was widespread in all three species. In Chrysaora, the antiserum revealed nerve nets in
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