PLA0056
Rabbit anti-Phospho Chk1 (S317) Antibody, Affinity Purified
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
primate, rhesus monkey, human, dog, chimpanzee, gorilla, pig, rabbit, horse
concentration
1 mg/mL
technique(s)
western blot: 1:500- 1:5,000
accession no.
NP_001265.1
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Gene Information
human ... CHEK1(1111)
Immunogen
Immunogen for PLA0056 was a phosphorylated synthetic peptide, which represented a portion of human Checkpoint Kinase 1 (GeneID 1111) around serine 317 according to the numbering given in entry NP_001265.1.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
Other Notes
Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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B P Kaistha et al.
British journal of cancer, 111(9), 1780-1787 (2014-08-20)
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of the disease during the past decade, the median survival rate (∼6 months) has hardly improved
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