PLA0086
Rabbit anti-ATM Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
Synonym(s):
A-T mutated, AT mutated, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A; C and D), homolog, homolog (S. cerevisiae), telomere maintenance 1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Species reactivity:
human
Technique(s):
immunohistochemistry: 1:500- 1:2,000, immunoprecipitation (IP): 3-7 μg/mg, western blot: 1:5,000- 1:25,000
Application:
IHC, IP, WB
Citations:
1
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
human
concentration
1 mg/mL
technique(s)
immunohistochemistry: 1:500- 1:2,000, immunoprecipitation (IP): 3-7 μg/mg, western blot: 1:5,000- 1:25,000
accession no.
Q13315
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
rabbit ... ATM(472)
Immunogen
The epitope recognized by PLA0086 maps to a region between residues 2550 and 2600 of human ataxia telangiectasia mutated using the numbering given in SwissProt entry Q13315 (GeneID 472).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Liu-Ya Tang et al.
The Journal of biological chemistry, 295(52), 18485-18493 (2020-10-25)
Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PLA0086-100UL | 04061837717338 |