PLA0091
Rabbit anti-CTBP1 Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
Synonym(s):
BARS, CtBP1, brefeldin A-ribosylated substrate
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
technique(s)
western blot: 1:1,000-1:5,000
accession no.
Q13363
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
rabbit ... CTBP1(1487)
General description
The CTBP1 (C-terminal binding protein 1) gene is mapped to human chromosome 4p16.3 and codes for transcriptional corepressor protein. The encoded protein exists in two isoforms : CtBP1-L and CtBP1-S. The CtBP1 family of proteins contains transcription factor-binding domain at N-terminal, a dehydrogenase domain and a C-terminal domain associated with substrate binding stabilization.
Immunogen
The epitope recognized by PLA0091 maps to a region between residues 400 and 440 of human C-terminal Binding Protein 1 using the numbering given in Swiss-Prot entry Q13363 (GeneID 1487).
Biochem/physiol Actions
CTBP1 (C-terminal binding protein 1) is an oncogenic gene, highly expressed in several cancers such as ovarian cancer. Ctbp1 serves as a transcription factor that performs its regulatory action along with Ctbp2. CTBP1 expression contributes to embryogenesis and is also associated with the lifespan of an individual. Ctbp1 induces tumor proliferation, metastasis, and epithelial-mesenchymal transition, also offers resistance to chemotherapy. Ctbp1 regulates the pro-apoptotic genes by suppressing its expression and maintains mitotic fidelity in order to sustain cell survival.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
CTBP1 was first identified as a protein that interacted with adenovirus E1A oncoproteins. CTBP1 has been found to be a highly conserved transcriptional corepressor. CTBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Through its association with centrosomes, CTBP1 appears to also play a role in mitosis and Golgi complex organization.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells.
Zhang Y, et al.
Oncotarget, 7(10), 11397-11397 (2016)
The miR-644a/CTBP1/p53 axis suppresses drug resistance by simultaneous inhibition of cell survival and epithelial-mesenchymal transition in breast cancer.
Raza U, et al.
Oncotarget, 7(31), 49859-49859 (2016)
CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors.
Dcona M M, et al.
Cancer Biology & Therapy, 18(6), 379-391 (2017)
Oligomeric form of CtBP coactivates NeuroD1-mediated transcription.
Ray S K, et al.
FEBS Journal, 591(1), 205-212 (2017)
Unusual 4p16.3 deletions suggest an additional chromosome region for the Wolf?Hirschhorn syndrome?associated seizures disorder.
Zollino M, et al.
Epilepsia, 55(6), 849-857 (2014)
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