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Merck
CN

PLA0093

Rabbit anti-SRC1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

F-SRC-1, Hin-2 protein, KAT13A, NCoA-1, PAX3/NCOA1 fusion protein, Protein Hin-2, RIP160, SRC-1, SRC1, Steroid receptor coactivator 1, bHLHe42, bHLHe74, class E basic helix-loop-helix protein 74, renal carcinoma antigen NY-REN-52, steroid receptor coactivator-1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry: 1:500-1:2,000, immunoprecipitation (IP): 2-10 μg/mg, western blot: 1:2,000-1:10,000

accession no.

NP_003734.3

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Gene Information

rabbit ... SRC1(8648)

Immunogen

The epitope recognized by PLA0093 maps to a region between residues 600 and 650 of human Nuclear Receptor Coactivator 1 using the numbering given in entry NP_003734.3 (GeneID 8648).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

Steroid receptor coactivator 1 (SRC1) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC1contains histone acetyltransferase (HAT) activities and may facilitate transcription through chromatin remodeling. SRCs associate with p300/CBP-associated factor and CREB binding protein (CBP) as part of a multisubunit coactivating complex.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Angeles Alvarez Secord et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 24(2), 218-225 (2014-01-11)
This study aimed to explore the activity of dasatinib in combination with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells. Cells with previously determined SRC pathway and protein expression (SRC pathway/SRC protein IGROV1, both high; SKOV3, both low) were
Mattia Capulli et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(8), 1833-1846 (2014-03-13)
Chondroadherin (CHAD) is a leucine-rich protein promoting cell attachment through binding to integrin α2 β1 and syndecans. We observed that CHAD mRNA and protein were lower in bone biopsies of 50-year-old to 65-year-old osteoporotic women and in bone samples of
Nazanin Ghazanfari et al.
The Journal of physiology, 592(13), 2881-2897 (2014-05-27)
Muscle-specific kinase (MuSK) autoantibodies from myasthenia gravis patients can block the activation of MuSK in vitro and/or reduce the postsynaptic localization of MuSK. Here we use a mouse model to examine the effects of MuSK autoantibodies upon some key components
M Ferrandi et al.
Human molecular genetics, 23(16), 4371-4382 (2014-04-05)
Mutant α-adducin and endogenous ouabain levels exert a causal role in hypertension by affecting renal Na-K ATPase. In addition, mutant β-adducin is involved in glomerular damage through nephrin down-regulation. Recently, the salt-inducible kinase 1 (SIK1) has been shown to exert
Sireesha V Garimella et al.
Breast cancer research : BCR, 16(2), R41-R41 (2014-04-22)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with
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