CN
All Photos(1)

PLA0095

Sigma-Aldrich

Rabbit anti-SRC3 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
RAC-3, TNRC16, SRC-3, CBP-interacting protein, amplified in breast cancer 1 protein, ACTR, TNRC14, receptor-associated coactivator 3, KAT13B, SRC3, NCoA-3, AIB-1, bHLHe42, class E basic helix-loop-helix protein 42, pCIP, p/CIP, CTG26, steroid receptor coactivator protein 3, TRAM-1, thyroid hormone receptor activator molecule 1, AIB1, RAC3, CAGH16
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

application(s)

immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000-1:10,000

accession no.

NP_858045.1

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... SRC3(8202)

General description

Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator,. It belongs to the p160 SRC family. SRC-3 is located on human chromosome 20q13.

Immunogen

The epitope recognized by PLA0095 maps to a region between residue 900 and 950 of human Steroid Receptor Coactivator 3 using the numbering given in entry NP_858045.1 (GeneID 8202).

Biochem/physiol Actions

Steroid receptor coactivator-3 (SRC-3) participates in the genesis and development of various cancers. SRC-3 possesses histone acetyltransferase activity. It modulates the expression of target genes, that participates in various biological processes, such as cell proliferation, differentiation and migration. SRC-3 increases the migration and invasion of esophageal squamous cell carcinoma (ESCC) cells.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

Steroid receptor coactivator 3 (SRC3) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC3 is an oncogene that is reported to be amplified and/or overexpressed in breast and gastric cancer and stimulates AKT signaling and cell growth and tumorigenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

NCOA3 (nuclear receptor coactivator 3)
Anzick, Sarah L
Cancer Medicine (2005)
NCOA3 (nuclear receptor coactivator 3)
Anzick, Sarah L
Cancer medicine (2005)
Overexpression of SRC-3 promotes esophageal squamous cell carcinoma aggressiveness by enhancing cell growth and invasiveness
Xu F P, et al.
Cancer medicine, 5(12), 3500-3511 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service