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Merck
CN

PLA0122

Rabbit anti-Chk2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

CDS1, CHK2, CHK2 (checkpoint; S.pombe) homolog, CHK2 checkpoint homolog, CHK2 checkpoint homolog (S. pombe), Checkpoint kinase 2, HuCds1, LFS2, PP1425, RAD53, bA444G7, cds1 homolog, checkpoint-like protein CHK2, hCds1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human

technique(s)

immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:2,000-1:10,000

accession no.

NP_009125.1

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Gene Information

rabbit ... Chk2(11200)

Immunogen

The epitope recognized by PLA0122 maps to a region between residues 1 and 50 of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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