Rabbit anti-NFRKB Antibody, Affinity Purified

The epitope recognized by PLA0190 maps to a region between residue 1025 and 1075 of human nuclear factor related to kappaB binding protein using the numbering given in entry AAH63280.1 (GeneID 4798).

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.

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